CYP19A1

(redirected from microsomal monooxygenase)

CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Recent findings indicate that free radicals species, namely hydroxyethyl radicals are generated during ethanol metabolism by microsomal monooxygenase system and particularly by the ethanol -inducible form of cytochrome P-450 (CYP2E1) that enhances liver damage by chronic ethanol exposure [4, 5].
Age related effects of heat stress on protective enzymes for peroxides and microsomal monooxygenase in rat liver.
Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat.
Bronchiolar epithelial damage and impairment of pulmonary microsomal monooxygenase activity in mice by naphthalene.
Some findings on the increased activity of microsomal monooxygenases in rat tissues after chronic (4-month) exposure to pseudocumene at the concentration of 10 mg/[m.sup.3] (c.a.
Yu, "Allelochemical induction of hormone-metabolizing microsomal monooxygenases in the fall armyworm," Zoological Studies, vol.
Iqbal and Wright (1997) reported that there might be the involvement of microsomal monooxygenases and / or esterases in resistance to abamectin with a limited evidence of involvement of glutathione-S-transferases.