microsomal enzyme

microsomal enzyme

Any of the catabolic drug-metabolising enzymes on the smooth endoplasmic reticulum of liver, kidneys, gastrointestinal tract.
 
Types
• UDP-Glucuronyl transferases.
• Cytochrome P450 isoforms
• Mixed-function oxidases (MFOs), which require NADPH and O2.
References in periodicals archive ?
Klaassen, "Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers," Toxicological Sciences, vol.
In the adrenal cortex, this is processed into either glucocorticoids and androgens in zona fasciculate and zona reticularis (which contain the microsomal enzyme cytochrome P450c17[alpha]-hydroxylase: P450c17 and 17,20 lyase) or into mineralocorticoids in zona glomerulosa (which does not contain P450c17 and 17,20 lyase, but contains aldosterone synthase, CYP11B2).
AST is a microsomal enzyme that is found in large amounts in the liver and with destructive liver tissue, is released in the blood in large amounts [19].
During phase I metabolism, drug molecules are transformed through oxidation or reduction of hydrolysis reactions by the action of a family of enzymes called the Cytochrome P450 (CYP) or microsomal enzyme system.
DGAT is a microsomal enzyme expressed in the liver and rate-limited enzyme in the process of TG synthesis, catalyzes the final step in TG synthesis by converting diacylglycerol and fatty acylcoenzyme A into TC (Farese et a).
For assay after incubation of chemicals with the rat liver microsomal enzyme system, a sample from the incubation mixture was subjected to the assay as described above.
Results did demonstrate that TBT neither directly inhibits the ATAT enzyme responsible for the fatty acid esterification of testosterone, nor does it suppress levels of the microsomal enzyme, as determined though activity assays following in vivo exposure to TBT.
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
The reaction mixture contained 0.1 M potassium phosphate buffer (pH 7.5), 3 mM NADH, 5 mM potassium ferriciyanide and microsomal enzyme in a final volume of 1.0 ml.
The hepatoprotective effect may be mediated through combination of multiple mechanisms, such as reported anti-oxidant, free radical scavenging, anti-inflammatory, calcium channel blocking and/or microsomal enzyme inhibitory action.

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