MITF

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MITF

Microphthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.
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References in periodicals archive ?
[7] Tumour cells may also label for MART-1 (melan-A/A103), tyrosinase, and microphthalmia transcription factor. [7]
Melan A and microphthalmia transcription factor were expressed in 52.17% and 4.34% of cases, respectively.
Both TFE3 and TFEB belong to the microphthalmia transcription factor (MiTF) subfamily.
Microphthalmia transcription factor. A sensitive and specific melanocyte marker for melanomadiagnosis.
These results suggest that, in contrast to the currently available first-generation melanocytic markers such as S100, microphthalmia transcription factor (MITF), and Martl/Melan A, (14-18) R21 immunohistochemistry can be used to distinguish melanoma from benign melanocytic proliferations and may be useful in the subclassification of melanoma.
Microphthalmia transcription factor (MiTF) is a nuclear protein involved in the development of melanocytes and the regulation of melanin synthesis in melanocytic lesions (13,14);it may be expressed by macrophages, lymphocytes, fibroblasts, Schwann cells, and smooth muscle cells.
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
To confirm the presence of melanoma, S100 should be combined with 1 or more markers with higher specificity, such as HMB-45, Melan-A/MART-1, tyrosinase, or microphthalmia transcription factor protein.
(7) Lymphangioleiomyomatosis cells coexpress contractile proteins (mainly [alpha]-smooth muscle actin and desmin) (Figure 5), melanocytic markers such as HMB-45, HMSA-1, MelanA/Martl, and microphthalmia transcription factor (MiTF) (Figures 6 and 7) and estrogen and progesterone receptors.
Microphthalmia transcription factor is necessary for the development of melanocytes during embryogenesis.
(24-26) Another melanocytic marker, microphthalmia transcription factor (MiTF), has been evaluated for possible use in the differential diagnosis of DMM and other spindle cell proliferations of the skin.