micropapillary urothelial carcinoma

micropapillary urothelial carcinoma

A uncommon variant of urothelial (transitional cell) carcinoma that presents in older (average age 76) adults, more commonly in men, which is histologically high grade, deeply invasive (into muscularis propria) and metastastatic, variably accompanied by in situ carcinoma.

DiffDx
Metastatic micropapillary carcinoma, papillary (e.g., renal cell) carcinoma.

Management
Immediate radical cystectomy.

Prognosis
Poor: all patients die within two years.
References in periodicals archive ?
Abbreviations: con UC, conventional urothelial carcinoma; MP UC, micropapillary urothelial carcinoma (hematoxylin-eosin, original magnification X100 [D, leftmost]; immunohistochemical stains, original magnification X100 [D]).
[37,14] Micropapillary urothelial carcinoma is a unique variant of urothelial carcinoma that comprises 0.7%-6% of all cases of urothelial cancers.
Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERRBB2 (HER2) amplification identifies patients with poor outcome.
Micropapillary urothelial carcinoma is recognized as a rare and aggressive variant of urothelial carcinoma, which often presents at a high-stage.
Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome.
Micropapillary urothelial carcinoma. Multiple small clusters of neoplastic urothelial cells in the same lacunar space is a reliable feature of this subtype and is often associated with back-to-back lacunar spaces (hematoxylin and eosin, original magnification X100).
Invasive micropapillary urothelial carcinoma of the bladder.
(8) A direct extension of a micropapillary urothelial carcinoma was highly unlikely.
Micropapillary urothelial carcinoma (MPUC) is a rare, clinically aggressive histologic variant of urothelial carcinoma (UC).
Micropapillary urothelial carcinoma was initially described as a histologic variant of conventional urothelial carcinoma with an aggressive clinical course.1 It comprises 0.6% to 1% of UC cases and has a male predominance (5:110:1) that is higher than in conventional UC (3:1).
Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 24 cases.
Micropapillary urothelial carcinoma (MPUC) is a rare variant of urothelial carcinoma.