(29,30) Piperine has a synergistic effect with CUR in reduction of micronucleus
frequency in lymphocytes at a low concentration of CUR (5 [micro]g/mL).
Use of the cytokinesis-blocked micronucleus
assay to detect gender differences and genetic instability in a lung cancer casecontrol study.
Lymphocytes obtained from obese subjects exposed for 24 hours to Sibutramine or Femproporex treatments at different concentrations (5.0, 10 and 20 [micro]g / mL of medium) did not significantly increase (P> 0.05) the number of binucleate cells with micronucleus
, when compared with the negative control treatment, with the exception of treatment with Sibutramine at 20 [micro]g / mL concentration of medium.
The presence of few cells with micronucleus
is considered as normal in humans.
The results of in vivo micronucleus
assay are given in Table 1.
evaluated the radioprotective effect of a combined regime, including melatonin and amifostine on sister chromatid exchange (SCE) and cytokinesis-block micronucleus
(CBMN) in human peripheral blood lymphocytes.
An application of acridine orange fluorescent staining to the micronucleus
Although different tests are available, in the present study, ethidium bromide/acridine orange viability staining and micronucleus
assay were used.
Effects of griseofulvin in medium-term liver carcinogenesis assay and peripheral blood micronucleus
test in rat.
is a parameter used to evaluate the mutagenic potential of substances, because is the result of the absence or incorrect repair of alterations in the parental cells, being considered an effective and simple test for mutagenicity analysis .
can be defined as a microscopically visible, round-to-oval cytoplasmic chromatin mass next to the nucleus.
In summary, the data generated in this study indicate that the AO and AN do not cause genetic damage, and they have a protective effect against micronucleus
formation in mice treated with doxorubicin.