micronucleus


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micronucleus

 [mi″kro-noo´kle-us]
1. in ciliate protozoa, the kinetoplast, the smaller of two types of nucleus in each cell, which functions in sexual reproduction.
2. a small nucleus.

mi·cro·nu·cle·us

(mī'krō-nū'klē-ŭs),
1. A small nucleus in a large cell, or the smaller nuclei in cells that have two or more such structures.
See also: macronucleus (2).
2. The smaller of the two nuclei in ciliates dividing mitotically and bearing specific inheritable material.
See also: macronucleus (2). Synonym(s): gametic nucleus, germ nucleus, gonad nucleus, karyogonad, reproductive nucleus

mi·cro·nu·cle·us

(mī'krō-nū'klē-ŭs)
1. A small nucleus in a large cell, or the smaller nuclei in cells that have two or more such structures.
2. The smaller of the two nuclei in ciliates dividing mitotically and bearing specific inheritable material.
See also: macronucleus (2)

micronucleus

the smaller of two nuclei found in some protozoans which is concerned with cell division. Compare MACRONUCLEUS.
References in periodicals archive ?
(29,30) Piperine has a synergistic effect with CUR in reduction of micronucleus frequency in lymphocytes at a low concentration of CUR (5 [micro]g/mL).
Use of the cytokinesis-blocked micronucleus assay to detect gender differences and genetic instability in a lung cancer casecontrol study.
Lymphocytes obtained from obese subjects exposed for 24 hours to Sibutramine or Femproporex treatments at different concentrations (5.0, 10 and 20 [micro]g / mL of medium) did not significantly increase (P> 0.05) the number of binucleate cells with micronucleus, when compared with the negative control treatment, with the exception of treatment with Sibutramine at 20 [micro]g / mL concentration of medium.
The presence of few cells with micronucleus is considered as normal in humans.
evaluated the radioprotective effect of a combined regime, including melatonin and amifostine on sister chromatid exchange (SCE) and cytokinesis-block micronucleus (CBMN) in human peripheral blood lymphocytes.
Although different tests are available, in the present study, ethidium bromide/acridine orange viability staining and micronucleus assay were used.
Effects of griseofulvin in medium-term liver carcinogenesis assay and peripheral blood micronucleus test in rat.
The micronucleus is a parameter used to evaluate the mutagenic potential of substances, because is the result of the absence or incorrect repair of alterations in the parental cells, being considered an effective and simple test for mutagenicity analysis [22].
[6] Micronucleus can be defined as a microscopically visible, round-to-oval cytoplasmic chromatin mass next to the nucleus.
In summary, the data generated in this study indicate that the AO and AN do not cause genetic damage, and they have a protective effect against micronucleus formation in mice treated with doxorubicin.