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A small, osmiophilic, cordlike twisted organelle found in the anterior region of many sporozoans; one of the characteristics that helps to define the subphylum Apicomplexa.
Synonym(s): sarconeme
[micro- + G. nēma, thread]
Farlex Partner Medical Dictionary © Farlex 2012
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Eukaryotic plasmids with toxoplasma gondii dense granule antigen (GRA 5) and microneme 3 (MIC3) genes as a cocktail DNA vaccine and evaluation of immune responses in BALB/C mice.
Barois et al., "Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division," PLoS Pathogens, vol.
Zhou et al., "Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate againsttoxoplasmosisinmice," Vaccine,vol.
(14.) Zhang, L., Maa, L., Liua, R., Zhanga, Y.., Zhanga, S., Hua, C., Songa, M., Caib, J., Wanga, M., Eimeria tenella heat shock protein 70 enhances protection of recombinant microneme protein MIC2 subunit antigen vaccination against E.
Klinman et al., "In ovo administration of CpG oligodeoxynucleotides and the recombinant microneme protein MIC2 protects against Eimeria infections," Vaccine, vol.
Full-length AMA1 is an 83-kDa polypeptide that is translocated to the apical organelle microneme at the time of invasion [13, 14], when the 83-kDa polypeptide undergoes N-terminal processing to form a 66-kDa form that is translocated to the merozoite surface 1,15].
Some sporozoites that are deficient in cell migration, such as spect (sporozoite microneme protein essential for cell traversal)-/- or spect2-/- sporozoites, are immobilized in the dermis, associated with CD11b+ cells, and destroyed by phagocytes [15].
Tomley, "Microneme proteins in apicomplexans," Sub-Cellular Biochemistry, vol.
The protein, identified by researchers from Boston College as DOC2.1, plays a similar role in the secretion of microneme organelles that are crucial to the mobility of the parasitic protozoa Toxoplasma gondii, which causes toxoplasmosis, and Plasmodium falciparum, which causes malaria.
N-terminal-tagged GST-VP1s from BKV, JCV, and simian virus 40 (SV40) were generously provided by Michael Pawlita (16), and GST-tagged microneme (Mic) protein encoded by Toxoplasma gondii was provided by David Sibley.
A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii.
tenella and known to encode a microneme adhesion involved in parasite motility and host cell invasion by the parasite (Lillehoj et al.