After anodization, a 3D microneedle
array structure with large AAO surface area can be formed.
Microneedling have shown to start collagen formation and production of healing agents but without removing epidermis and without causing hyperpigmentation.8 Hence microneedle
therapy promotes healing with less epidermal damage and small recovery time than other ablative or resurfacing techniques.9
"This is maybe 5 or 10 years off in the future, but this method could be painless upon delivery of antigen on either coated solid microneedles
or within dissolving microneedles
only to the epidermis, which lacks nerve endings," Dr.
With our new dry powder and microneedle
technologies, 3M can fulfill DPI and MDI inhalation needs as well as both passive and active transdermal manufacturing.
Insertion of microneedles
into skin: measurement and prediction of insertion force and needle fracture force[J].
Engineers Mark Prausnitz and Mark Allen at the Georgia Institute of Technology have developed a skin patch of microneedles
(needles thinner and shorter than the diameter of a human hair), which they hope will eventually deliver painless medication.
When the disk of sugar that makes up the capsule dissolves, a spring within releases a microneedle
that it made of freeze-dried insulin.
Researchers at CUMC and the University of North Carolina have designed a microneedle
skin patch that delivers fat-shrinking drugs locally.
The closed balloon provides a protective covering for a tiny, perpendicular-oriented injection microneedle
as it is guided safely through the vascular system to target vessels with diameters of 2 to 8 millimetres.
Specific transdermal and intradermal drug delivery techniques are then described, including techniques such as cryo-TEM, microcorporation, microneedle
technology, film-forming and heated systems, nanotechnology-based applications, and magnetophoresis.