The threshold used for the 2 datasets was slightly different because the case mixes were different (eg, macrometastasis versus micrometastasis
; Table 1).
(3) Tumor cell dissemination, also referred to as micrometastasis
, can be seen in bone marrow in roughly one third of the patients with breast cancer.
Secondly, there is undetected nodal micrometastasis
of our patients.
Naume et al., "A pooled analysis of bone marrow micrometastasis
in breast cancer," The New England Journal of Medicine, vol.
However, "microscopic" only means that the disease is in a different moment in time, but it is still the same disease, and so, one can decide at which moment to intervene in the natural evolution of the disease, be it at a later stage (large lymph nodes), or earlier stage (micrometastasis
However, before the surgical procedure, chemotherapy is given for 10 weeks to better demarcate tumor margins, shrink tumor size, and combat micrometastasis
. After the chemotherapy protocol has been completed, an above-the-knee amputation is performed.
Una de las limitaciones, es que no existen biomarcadores que puedan predecir el riesgo de micrometastasis
, para permitir mayores tasas de conservacion del globo ocular.
Migration of tumor cells by saliva (micrometastasis
) [Figure 1b].
condition required chemotherapy to kill the primary neoplasm and hidden micrometastasis
cells before it gets spread and it can be detected by physical examination or x-rays and the success of breast cancer treatment can be measured after 5-years.
The term micrometastasis
has been replaced by "clinically occult disease" as detected by SLNB.
This technique frequently identifies isolated tumor cells and micrometastasis
(collectively called low-volume disease) in addition to macrometastasis.
In the other three cases, SNs were negative for the presence of micrometastasis
, as demonstrated by both multi-dissection and IHC analyses.