Similar with Z0011, the IBCSG 23-01 trial included only patients with micrometastases
at SLNB; patients were divided into two groups as ALND and no surgery.
We identified micrometastases
GFP tumors, determined the presence of red fluorescent imaging agent using highly sensitive cryo-fluorescence, determined if there was detectable MR signal, and examined histology for identification of tumor heterogeneity.
Aerosol therapy has the advantage of delivering agents directly to the lung, the organ where micrometastases
exist, resulting in increased drug concentration in the lung, decreased drug levels in the circulation, and decreased systemic toxicity .
Steininger et al., "Genetic detection of lymph node micrometastases
: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer," Transplantation, vol.
Pathological features, including tumor size (maximum diameter in centimeters), tumor border configuration (expanding or infiltrating), WHO histological grade , pTNM stage , TB, LVI, grading based on the counting of PDC , and the presence of lymph node micrometastases
(MM) , were available in all cases.
Then, to control the overall disease, we changed the patient's medication from bicalutamide to enzalutamide for potentially existing micrometastases
and added prostate RT (74 Gy).
Incipient tumors or micrometastases
? J Cancer Res Clin Oncol 1999;125:105.
Neoadjuvant chemotherapy will also help to reduce early micrometastases
The Incidence of Micrometastases
in Neck Dissection Specimens Obtained From Elective Neck Dissections.
The machine's increased sensitivity would be able to detect small, low-density tumor deposits known as micrometastases
. Currently, the standard is for all patients with metastasis risk indicators to receive chemotherapy, which can be toxic and expensive, and after which it's not possible to determine how effective the treatment was.
It improves detection of LN metastases by allowing detection of micrometastases
using ultrastaging (serial sectioning) of target LNs.
In contrast to micrometastases
emanating from e.g., hormone-positive breast cancers, any distant TNBC micrometastases
are likely to shrink during neoadjuvant therapy and to be undetectable after breast cancer surgery by current ctDNA detection techniques.