micrometastases


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micrometastasis

(mī″krō-mĕ-tas′tă-sĭs) (′tă-sēz″) plural.micrometastases [ micro- + metastasis]
Any of the foci of tumor cells that are invisible to the naked eye or by routine imaging techniques but may be seen using microscopy with special stains or antibodies or by other laboratory techniques.

micrometastases

Small collections of cancer cells, discernible only on microscopic examination, occurring in the lymph nodes of people with cancer. They may occur in treated cancer patients and identify a high-risk group among those previously deemed to be free of the disease.
References in periodicals archive ?
Women with micrometastases were found to have significantly better 8-year OS compared with women with macrometastases (>2 mm; 17 of 18 patients [94%] versus 28 of 45 patients [62%]).
7] Micrometastases will be detected in more instances with serial deeper levels than with fewer sections from the surface of the wax block only.
Augmented immune response against tumor-specific antigens is a secondary benefit; potential irradication of systemic micrometastases and reduced tumor recurrence rate compared with results of surgical excision has been demonstrated in animal studies.
Immunohistochemical detection of micrometastases in pelvic lymph nodes from patients with urothelial cancer of the urinary bladder.
Histopathological examination of the SLN paraffin-embedded sections revealed that 18 patients had macrometastatic spread to the SLNs and 6 had micrometastases in the SLNs (Table 2).
Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction.
Molecular detection of sentinel node micrometastases in patients with clinical N0 gastric carcinoma with real-time multiplex reverse transcription-polymerase chain reaction assay.
Disseminated tumor cells (DTCs) and micrometastases can remain in a dormant state for many years after complete resection of the primary tumor before they give rise to overt metastases (2).
Most anti-cancer agents, which rely on the differences in the proliferation rate of normal and tumor cells, have little effect on micrometastases because tumor cells distributed to distant organs often remain dormant.
Hunting for micrometastases in either sentinel lymph nodes or bone marrow isn't justified for these women, say the researchers.
O tratamento cirurgico do tumor mamario ainda permanece como principal forma de promover a cura do paciente, porem, a cirurgia como monoterapia pode nao ser eficaz uma vez que nao remove focos de micrometastases formados por celulas do tumor primario carreadas para novos sitios e essas micrometastases nao sao detectaveis em ultrassonografias e radiografias pre-operatorias (1).