Women with micrometastases
were found to have significantly better 8-year OS compared with women with macrometastases (>2 mm; 17 of 18 patients [94%] versus 28 of 45 patients [62%]).
will be detected in more instances with serial deeper levels than with fewer sections from the surface of the wax block only.
Augmented immune response against tumor-specific antigens is a secondary benefit; potential irradication of systemic micrometastases
and reduced tumor recurrence rate compared with results of surgical excision has been demonstrated in animal studies.
Immunohistochemical detection of micrometastases
in pelvic lymph nodes from patients with urothelial cancer of the urinary bladder.
Histopathological examination of the SLN paraffin-embedded sections revealed that 18 patients had macrometastatic spread to the SLNs and 6 had micrometastases
in the SLNs (Table 2).
Detection of breast cancer micrometastases
in axillary lymph nodes by using polymerase chain reaction.
Molecular detection of sentinel node micrometastases
in patients with clinical N0 gastric carcinoma with real-time multiplex reverse transcription-polymerase chain reaction assay.
Disseminated tumor cells (DTCs) and micrometastases
can remain in a dormant state for many years after complete resection of the primary tumor before they give rise to overt metastases (2).
Detection of lymph node micrometastases
in patients with squamous carcinoma of the head and neck.
Most anti-cancer agents, which rely on the differences in the proliferation rate of normal and tumor cells, have little effect on micrometastases
because tumor cells distributed to distant organs often remain dormant.
Hunting for micrometastases
in either sentinel lymph nodes or bone marrow isn't justified for these women, say the researchers.
O tratamento cirurgico do tumor mamario ainda permanece como principal forma de promover a cura do paciente, porem, a cirurgia como monoterapia pode nao ser eficaz uma vez que nao remove focos de micrometastases
formados por celulas do tumor primario carreadas para novos sitios e essas micrometastases
nao sao detectaveis em ultrassonografias e radiografias pre-operatorias (1).