Lettieri et al., "Emotion recognition in Parkinson's disease after subthalamic deep brain stimulation: differential effects of microlesion
and STN stimulation," Cortex, vol.
Maltete et al., "Decline in verbal fluency after subthalamic nucleus deep brain stimulation in Parkinson's disease: a microlesion
effect of the electrode trajectory," Journal of Parkinson's disease, vol.
Events related to surgery: A "microlesion
effect" was observed shortly after DBS surgery in all of the patients, lasting for 1-2 weeks.
We tested the hypothesis that the creation of a focal microlesion
in hippocampus elicits self-repair mechanisms mediated by cytokines which activate microglia, promote astrocytosis, and stimulate stem/progenitor cells to proliferate and generate new neurons.
For hemisection injury, a microlesion
knife (Fisher Scientific, Pittsburgh, PA) marked at 1.2 mm from the tip was lowered into the spinal cord at a depth of 1.2 mm from the dorsal-most point and drawn laterally across the dorsal aspect of the spinal cord.
But, according to the published study, some of this initial benefit could be attributable to the microlesion
effect, "commonly observed in Parkinson's disease where the mere insertion of a DBS electrode can produce transient clinical benefits." By 2 weeks, the response rate had fallen to 30% (six patients), consistent with this theory.
Because PD and ET patients often have a "microlesion
effect" (symptom reduction immediately after surgery; Kumar, 2002) medications were held before testing for both ET and PD patients when necessary, to allow symptoms to manifest and permit effective testing.
Programming is usually not initiated immediately after the placement of a lead; instead a time frame of 2-4 weeks is allowed for the microlesion
effects to fade away.
The mere passage of an electrode through the STN may suppress motor symptoms or induce adverse temporary changes because of a "microlesion
Figure 1(b) shows that even very small microlesions
containing only 4 to 15 BCC cells are visualized clearly and easy to find with BerEP4 staining.
Our previous study on BerEP4 use conducted by Tan & Sunjaya (2016) on 23 specimens with 394 microlesions
also showed 100% positive results with 100% sensitivity and specificity.
Gao et al., "Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions
that disrupt cardiac function," PLoS Pathogens, vol.