* Clearside Biomedical, Inc.(NASDAQ: CLSD) climbed 16% to close at $0.68 after the company announced an option and license agreement for exclusive worldwide rights to its SCS Microinjector
Regenxbio (RGNX) and Clearside Biomedical (CLSD) announced an option and license agreement for exclusive worldwide rights to Clearside's proprietary, in-office SCS Microinjector
for the delivery of RGX-314 to the suprachoroidal space to treat wet age-related macular degeneration, or wet AMD, diabetic retinopathy, or DR, and other conditions for which anti-vascular endothelial growth factor, or anti-VEGF, treatment is currently the standard of care.
The requested data does not relate to or affect the SCS Microinjector
gemmatalis using a 1 mL insulin syringe and a microinjector
(Burkard, Rickmansworth, United Kingdom).
After allowing time for melt homogenization, the alloy was taken out and aspirated into a microinjector
. Pure Cu plates (>99.9%) in a size of 15 x 15 x 4 [mm.sup.3] were used as substrates.
Ganoderic acid A solution and samples a to k (5 [micro]L) were spotted using a microinjector
on a 20 x 20 cm silica gel plate (GF254, Qingdao, China).
The injection rate was programmed to 10 [micro]l/min, using a precalibrated microinjector
Then, two groups of animals (n = 6, each group) were anesthetized with a mix of ketamine-xylazine solution (1 ml/kg) and placed on a stereotaxic apparatus (KOPF Mod 5000, USA); then, stereotaxic injections were made by using a 10 [micro]l Hamilton syringe (model 701) coupled in manual microinjector
with a velocity of 106 nl per revolution (Sutter Instrument USA).
The aqueous humor samples were collected using a microinjector
(Hamilton 1710 RN, SYR 100 [micro]L, Swiss).
A retrograde labelling of the vagus nerve was achieved with 1,1'-dioctadecyl3,3,3',3'- tetramethylindocarbocyanine perchlorate (Dil, Life Technologies Corporation, CA, USA), a fluorescent tracer, which was injected into the liver by a microinjector
, to rule out an incomplete vagotomy.
Protein samples (8 ug) were loaded in each sample hole using the microinjector
, Electrophoresis was conducted at 120 V and 4degC.