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The overall area of the infarcts is generally unchanged and can be controlled, as indicated by a preliminary experiment showing dose-dependent but unpredictably distributed microinfarcts.
Vega et al., "Longitudinal monitoring of mesoscopic cortical activity in a mouse model of microinfarcts reveals dissociations with behavioral and motor function," Journal of Cerebral Blood Flow & Metabolism, 2018.
T[degrees]e insportance of microinfarcts as a physical sign should riot be underestimated.
Microbleed and microinfarct detection in amyloid angiopathy: A high-resolution mri-histopathology study.
This has been attributed mainly to the ability of serum troponins to detect microinfarcts, areas of necrosis too small to produce electrocardiographic changes or increased serum cardiac enzymes.
These droplets can either become lodged in the pulmonary circulation or pass into the systemic circulation and lodge in the cerebral vasculature causing microinfarcts .
Cerebral small-vessel disease, including leukoaraiosis, lacunes, microinfarcts, brain atrophy, and enlarged perivascular spaces, has been proved to be crucial in the progression of vascular cognitive impairment and mixed dementia, and it might strongly associate with carotid atherosclerosis.[sup] Carotid atherosclerosis strongly associated with small cerebral vessel disease, and the pathological pathway between them could be attributed to microembolism and shared risk factors.
Scattered microinfarcts were present in cerebellum, lateral thalamus, and frontal cortex.
Recent studies indicate that hypertension might potentiate the impact of Alzheimer's disease and its role in causing microbleeds, microinfarcts, white matter disease, and multiple small strokes that might not be clinically noticeable at the time but can lead to dementia, as well as possible involvement in the accumulation of amyloid plaques in the brain (10,11).
Recent research suggests, however, that other pathologies linked with dementia--such as Lewy bodies (abnormal deposits of a protein inside brain cells), hippocampal sclerosis (a severe loss of brain cells in a key memory region called the hippocampus), microinfarcts (small mini-strokes) and low brain weight--are also commonly present in the brains of individuals with dementia.
For example, primary open-angle glaucoma has been significantly associated with cerebral microinfarcts , stroke , and dementia .
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