Astrocytosis confirmed by GFAP immunostaining (GRAESSER et al., 2006) and microgliosis
confirmed by Iba-1 immunostaining (SOFRONIEW & VINTERS, 2010) were also present in our case.
At a biochemical and molecular level, ASH ameliorated the HFD-induced reactive gliosis and microgliosis
and suppressed the expression of inflammatory markers such as RRARy, iNOS, MCP1, TNF[alpha], IL-1[beta] B and IL-6.
Youdim, "Iron involvement in neural damage and microgliosis
in models of neurodegenerative diseases," Cellular and Molecular Biology, vol.
It showed that masitinib exerted neuroprotection by controlling microgliosis
and neuroinflammation and ameliorating the aberrant glial cell proliferation in [SOD1.sup.G93A] rats .
Murugan et al., "Spinal microgliosis
due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury," Cell Reports, vol.
In a recently published study on APPswe/PS1[DELTA]E9 mice, researchers were unable to demonstrate the presence of amyloid plaques, dystrophic neurites, neuronal loss, macro- or microgliosis
, aberrant cell cycle re-entry, OS, tau hyperphosphorylation, or upregulation of proinflammatory cytokines or stress signaling molecules in the retina .
Connaughton et al., "Further characterisation of the LPS model of Parkinson's disease: a comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis
and nigrostriatal neurodegeneration in the rat," Brain, Behavior, and Immunity, vol.
Histologically, shared CNS lesions among the animals examined were moderate to marked lymphohistiocytic cell perivascular cuffing with marked vasculitis and neuronal degeneration, necrosis, and neurophagia with multifocal microgliosis
and satellitosis (Figure 4).
Ello es debido, en parte, a la falta de determinacion de la ventana de accion terapeutica del tratamiento, al hecho de tener en cuenta que luego de un evento isquemico se generan cambios fisiopatologicos diferentes que varian con respecto al tiempo post-lesion, por ejemplo: a pocas horas de la muerte celular, luego de varios dias, el proceso inflamatorio, la astrogliosis y la microgliosis
; y posterior a ello, luego de dias y semanas, aparece la perdida de espinas y dendritas que perduran a largo termino post-infarto y desencadenan asi perdida de funciones (Posada-Duque, Barreto, Cardona-Gomez, 2014).
The cytokine profiling array did not show diabetes-associated increases in classic proinflammatory cytokines such as IL-1[beta], TNF-[alpha], fractalkine, and IL-6 cytokines, which are associated with microgliosis
and hyperalgesia [11, 20, 28, 29,31,32].
S100B gene ablation in mice protected them against 1-methyl -4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP-) induced neurotoxicity via the reduction in microgliosis
and expression of RAGE and TNF-[alpha] receptor .
Bolin, "Compromised reactive microgliosis
in MPTP-lesioned IL-6 KO mice," Brain Research, vol.