microglial cell


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microglial cell

A perivascular bone-marrow-derived cell native to the CNS, belonging to the mononuclear phagocytic system (e.g., monocytes, macrophages, dendritic cells and granulocytes), which presents antigens in an MHC-class-II restricted context.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

microglial cell

A small glial cell of the central nervous system and retina. Microglia have spiky branched processes and are arranged homogeneously throughout the brain and spinal cord. They are activated by disease and injury, after which they become phagocytic and sometimes resume their embryonic motility like a macrophage.
See also: cell
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Evaluation of the functional recovery of the spinal cord in spinal cord injury rats between microglial cell transplantation group A and saline injection group B.
Previous studies have reported that various compounds exert the anti-inflammatory activity in microglial cells not only through inhibiting NF-[kappa]B pathway, but also through activating Nrf2 pathway and antioxidant response element (ARE), as well as through increasing the synthesis of some antioxidant enzymes, including HO-1 [54, 55].
SAH injury in brain leads to three physiological responses, namely, inflammation, microglial cell activation, and oxidative damage, which lead to cellular injury and cell death.
Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-[kappa]B activation and ERK phosphorylation.
Retinal microglial cells were transferred into 16-well chamber slides (Labtek Nunc, Thermo scientific, Leicestershire, UK) and allowed to adhere for 24 h.
Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells. J Neurosci Res 2002; 68 : 579-87.
Inflammation and coagulation gene expression in N9 microglial cell line, 24hrs following LPS treatment (b).
Eugenin, "Microglial cell dysregulation in brain aging and neurodegeneration," Frontiers in Aging Neuroscience, vol.
A study demonstrated that in BV2 microglial cell lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1[beta] cleavage caused by ATP.
N9 cell, a mouse microglial cell line, was obtained from the Fourth Military Medical University, China.