Evaluation of the functional recovery of the spinal cord in spinal cord injury rats between microglial cell
transplantation group A and saline injection group B.
Previous studies have reported that various compounds exert the anti-inflammatory activity in microglial cells
not only through inhibiting NF-[kappa]B pathway, but also through activating Nrf2 pathway and antioxidant response element (ARE), as well as through increasing the synthesis of some antioxidant enzymes, including HO-1 [54, 55].
SAH injury in brain leads to three physiological responses, namely, inflammation, microglial cell
activation, and oxidative damage, which lead to cellular injury and cell death.
Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells
by suppressing Akt-mediated NF-[kappa]B activation and ERK phosphorylation.
Retinal microglial cells
were transferred into 16-well chamber slides (Labtek Nunc, Thermo scientific, Leicestershire, UK) and allowed to adhere for 24 h.
Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells
. J Neurosci Res 2002; 68 : 579-87.
Inflammation and coagulation gene expression in N9 microglial cell
line, 24hrs following LPS treatment (b).
Eugenin, "Microglial cell
dysregulation in brain aging and neurodegeneration," Frontiers in Aging Neuroscience, vol.
A study demonstrated that in BV2 microglial cell
lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1[beta] cleavage caused by ATP.
The BV-2 mouse microglial cell
line was a kind gift from Dr.
N9 cell, a mouse microglial cell
line, was obtained from the Fourth Military Medical University, China.
"Somehow the microglial cell
may get put back on that pathway," Kettenmann says.