microglia


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Related to microglia: Astrocytes, Oligodendrocytes

microglia

 [mi-krog´le-ah]
non-neural cells forming part of the adventitial structure of the central nervous system. They are migratory and act as phagocytes of waste products of the nervous system. adj., adj microg´lial.

mi·crog·li·a

(mī-krog'lē-ă), This word is grammatically singular. Avoid the mispronunciation microgli'a.
Small neuroglial cells of the central nervous system, originating in the bone marrow, that may become phagocytic in areas of neural damage or inflammation.
[micro- + G. glia, glue]

microglia

(mī′krō-glē′ə, -glī′-)
n.
(used with a pl. verb) Any of the small neuroglial cells of the central nervous system having long processes and amoeboid and phagocytic activity at sites of neural damage or inflammation.

microglial cell

A perivascular bone-marrow-derived cell native to the CNS, belonging to the mononuclear phagocytic system (e.g., monocytes, macrophages, dendritic cells and granulocytes), which presents antigens in an MHC-class-II restricted context.

mi·crog·li·a

(mī-krog'lē-ă)
Small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation.
Synonym(s): Hortega cells.
[micro- + G. glia, glue]
Enlarge picture
MICROGLIA

microglia

(mi-krog'le-a) [? + glia, glue]
Cells of the central nervous system (CNS) present between neurons or next to capillaries. These cells may function as macrophages when they migrate to damaged CNS tissue.
See: gitter cell; illustration

microglia

Neurological connective tissue MACROPHAGES. Compare MACROGLIA.

Hortega,

Pio del Rio, Spanish neurohistologist in South America, 1882-1945.
Hortega cells - small neuroglial cells that may become phagocytic in areas of neural damage or inflammation. Synonym(s): microglia
Hortega neuroglia stain - one of several silver carbonate methods to demonstrate astrocytes, oligodendroglia, and microglia.
References in periodicals archive ?
Finally, microglia in the cell models were also "treated" with an antibiotic, minocycline, which proved to inhibit the synaptic pruning.
In mice with weakened microglia, more tau tangle-like structures formed near the amyloid plaques than in mice with functional microglia.
Researchers believe that at the onset of neurological disorders microglia present in the brain and spinal cord accumulate around injured neurons.
The microglia also decreased their expression of their sensome, a collection of proteins that the microglia use to sense their environment.
Then, 12 mmol/L lidocaine hydrochloride (pH: 7.2-7.4) was administered 10 min during culture to activate the microglia.
Researchers have relied predominantly on animal models, which do not sufficiently mimic the human disease, to study the role microglia play in neurodegeneration, the company said.
The team reports that the byproducts that microbes produce when they break down dietary tryptophan - an amino acid found in turkey and other foods - may limit inflammation in the brain through their influence on microglia.
Ikezu's lab has extensive experience in the cell biology of microglia, and has studied how the innate aspect of the central nervous system influences the pathology and progression of neurodegenerative disease.
Dheen, "HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke," Molecular Neurobiology, vol.
In the CNS, microglia play a critical role in tissue homeostasis and innate immunity by constantly removing infectious agents or unwanted cells.