Nonneoplastic cervical glandular lesions studied were tunnel clusters, DLEGH--Diffuse laminar endocervical glandular hyperplasia, and microglandular hyperplasia
in reproductive age group.
Microglandular hyperplasia consists of closely packed glands lined by low columnar or cuboidal cells with lumina containing mucin and inflammatory cells, particularly polymorphonuclear leukocytes.
44,47,51,53,54,74,177,182) However, microglandular hyperplasia may exhibit strong p16 positivity in greater than 50% of the cells (areas of squamous metaplasia may be either negative or weakly and focally positive).
252) Of note, constituent glands of both MDA and LEGH are ER negative, (226,252) while normal endocervical glands and benign lesions, namely, microglandular hyperplasia, (182,188) show nuclear ER positivity and a stromal immunoprofile that overlaps with that seen in LEGH.
58,283) On the other hand, p53 immunoreactivity in microglandular hyperplasia ranges from negative to focally positive.
123) Other pseudotumors with an endocrine underpinning include prostatic hyperplasias, (124,125) focal nodular hyperplasia of the liver (126) (Figure 14, A through D), ovarian stromal hyperthecosis, (127) the endometrial Arias-Stella reaction, (128) osteitis fibrosa cystica (brown tumor of hyperparathyroidism) (129,130) (Figure 15, A through D), and uterine cervical microglandular hyperplasia.
Microglandular hyperplasia of the cervix: unusual clinical and pathological presentations and their differential diagnosis.
Several such entities are discussed in this review, including microglandular hyperplasia of the cervix mimicking well-differentiated endometrial and endocervical adenocarcinoma, reactive epithelial changes in the fallopian tubes mimicking adenocarcinoma or carcinoma in situ, atypical and hyperplastic changes in endometriosis, and pregnancy changes in the ovary including pregnancy luteoma and large solitary luteinized follicular cyst of pregnancy and puerperium.
Several entities have been recognized as mimics of malignancy; amongst those, microglandular hyperplasia probably represents the most prominent example.
1) The term microglandular hyperplasia was first used by Kyriakos and coworkers (2) in 1968 for a cohort of patients taking oral contraceptives.
Benign lesions, including endometrial polyps, endometritis, endocervical polyps, endocervical tubal metaplasia, and endocervical microglandular hyperplasia, were recorded.
Benign histologic follow-up results of endometrial and endocervical polyps, endometritis, endocervical tubal metaplasia, and endocervical microglandular hyperplasia are summarized in Table 3.