Thus, upon reaching the large intestine, Shigella is taken up in vacuoles by
microfold cell (M cells) which are specialized structure of the follicle associated epithelium which covers the mucosal lymphoid follicles, the stimulating site of the mucosal immune system (45 46).
In localised areas covering the lymphoid tissues, another type, the
microfold cell (M Cell) is also present in small numbers.
GP2 is found in
microfold cells (M cells) of the follicular-associated epithelium in intestinal Peyer's patches (22).
The FAE
microfold cells (M cells) sample luminal antigens and present them in Peyer's patches [38].
Generally, some bioactive polysaccharides were considered to modulate systemic immunity through
microfold cells in the follicle-associated epithelium of the Peyer's patch (Volman et al.
(2012) The Ets transcription factor Spi-B is essential for the differentiation of intestinal
microfold cells. Nat.
The physical/chemical barriers composed by IEL, Paneth cells (PC),
microfold cells (M cells) or their products are impaired during the disease and fail to restrain bacterial invasion.
In addition to the pancreatic location of GP2, this glycoprotein was also detected on the
microfold cells (M cells) of intestinal Peyer's patches (PP) representing the follicle-associated epithelium (FAE) in the intestine [23].