With funding from the European Research Council and Cancer Research UK, my lab has been developing new models of the tumour microenvironment
. As I will describe in the Ideas Lab session, I have been using tissue engineering techniques to grow mini-human tumours in the lab.
"Tumors employ various strategies to create a tolerogenic microenvironment
, which reduces the immune system's ability to detect and fight cancer," said Courtney Beers, Ph.D., Vice President, Immunology, Tizona.
"Our findings suggest that a microenvironment
ripe for metastasis is generated at an earlier stage of the disease than previously recognized."
Solid tumours pose a big challenge to antibody therapies because they have microenvironments
whose conditions, such as low oxygen, make it difficult for immune cells to survive and do their work.
Fat cells, collagen fibers and epithelial cells make up the microenvironment
of breast tissue.
The advance will allow biomedical scientists to study the functioning of an individual's intestinal lining in a controlled microenvironment
, where the lining can interact with immune cells, blood cells and drugs, said Robert Barrett of the Regenerative Medicine Institute.
Embryonic and adult stem cell research has shown that stem cell fates are controlled by their specialized microenvironment
, referred to as the stem cell niche, via direct cell-cell interactions and the molecular signals emitting from the niche.
The Scientific World Journal and the authors have retracted the article titled "Inflammatory Microenvironment
Promotes Hemopoietic-Derived Angiogenic Cell Expansion and Arterial Specification" .
Thus, the microenvironment
is essential for tumor growth.
Macrophage Pharma's Esterase Sensitive Motif (ESM) technology enables delivery of novel, small molecule drug candidates to tumor associated macrophages in a selective manner to reverse immunosuppression established in the tumor microenvironment
, and could progress to provide a next-generation immunotherapy with broad utility in oncology.
They discuss general principles of evolution and ecology as they apply to cancer, the molecular mechanisms that underlie genetic heterogeneity within tumors, roles of the microenvironment
and spatial heterogeneity within tumors that provide selection pressures and drive the coevolution of cancer cells with their microenvironment
, and examples of how to incorporate novel technologies such as liquid biopsy into clinical practice to detect and monitor tumors during treatment.
In conjunction with bone marrow tissue cells, these HSCs form a microenvironment
known as a niche.