Keeping these in mind, the present study was designed to investigate the factors affecting serum ferritin level in school going healthy children in Distt Bannu, Khyber Pakhtunkhwa and to know the potential risk in children associated with hypoferritinemia, leading to microcytic hypochromic anemia
in our population.
The disease may first be noticed in childhood or in early adult life, when microcytic hypochromic anemia
and splenomegaly are noted.
Out of total 100 cases studied dimorphic anemia was more common among the children >6 years of age, microcytic hypochromic anemia
was more prevalent between 1-6 years of age and hemolytic anemia was most commonly seen in infants (< 1 year).
Mice lacking this peptide show progressive iron accumulation (26), whereas overexpression of hepcidin in mice leads to decreased iron stores and severe microcytic hypochromic anemia
at birth (27).
He had a microcytic hypochromic anemia
, and a hemoglobin of 1.11 mmol/L (7.2 g/dL).
In this study, cases of microcytic hypochromic anemia
are highest, i.e., 2410 (50.47%) which is most common in this area and the next common anemia is normochromic nonnocytic anemia (2260 [47.32%]) followed by dimorphic anemia, i.e., 314 (6.57%), hemolytic anemia, i.e., 193 (4.04%), macrocytic anemia, i.e., 188 (3.93%), pancytopenia, i.e., 51 (1.06%), and sickle cell anemia, i.e., 38 (0.79%) (Table 5).
The cases consisted of Normocytic normochromic anemia, Microcytic hypochromic anemia
, dimorphic anemia, Pancytopenia & Thalassemia, as diagnosed by peripheral smear.
Complete blood count showed severe microcytic hypochromic anemia
. Hemoglobin electrophoresis showed a prominent band in the S,D,G region.
In the patients with anemia, Peripheral smear examination showed majority to have Normocytic Normochromic blood picture with thrombocytopenia and three patients had Microcytic Hypochromic Anemia
Initial investigation revealed Hb 7gm% and there was microcytic hypochromic anemia
.TLC was 10,000 cumm, DLC 72/20 /8/oo, Platelet count 1.8 lacs, serum sodium 134/meq/l, and potassium 4.7 meq/l,blood urea 54mg/dl, serum creatinine 0.6 mg/dl.
The work up done at that time showed a Hb of 7.4gm/dl, PCV of 22, PBF showing microcytic hypochromic anemia
, suggestive of iron deficiency.
Normocytic normochromic anemia was the commonest type of anemia (55%) followed by microcytic hypochromic anemia
(27%), normocytic hypochromic anemia (11%), macrocytic (4%) and dimorphic (3%).