Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble
Effectiveness of localized ultrasound-targeted microbubble
destruction with doxorubicin liposomes in H22 mouse hepatocellular carcinoma model.
Upon this condition, the contrast infusion rate is correlated with the local blood flow velocity, and the microbubble
amount is correlated with the microvascular blood volume.
This major drawback is partially alleviated using an ultrasound contrast agent formed of gas microbubbles
. The echogenicity of the microbubbles
is immense in comparison to the echogenicity of the surrounding soft tissues.
Researchers found that microbubbles
conjugated to streptavidin can be coupled to the surface of a cell, where mechanosensitive Piezo1 ion channels are expressed.
CEUS performed with the use of a microbubble
contrast agent may be a potentially useful adjunct in assessing thyroid nodules, since it has a high specificity of 84.8% and high sensitivity of 76.9%.
Borden, "Ultrasound microbubble
contrast agents: fundamentals and application to gene and drug delivery," Annual Review of Biomedical Engineering, vol.
Therefore, the main objective of this work is to study the shape oscillations of a single microbubble
in an ultrasound field based on numerical simulation, and the relationship between the bubble shape variation period and the driving pressure period is investigated.
The "up arrow sign" was presented only when microbubble
formation was not detected even after all 15 consecutive micropulses.
For the ASA procedure, TEE may be useful to clearly observe and confirm the perfusion area of the target septal branch by injecting microbubble
contrast, if the patient undergoes TAVI with general anesthesia and TEE guidance.
Under the company's current trial, the research team will inject a commonly used sonographic microbubble
solution into the bloodstream of a patient with a malignant brain tumour.