microbicide


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microbicide

 [mi-kro´bĭ-sīd]
an agent that destroys microbes; see also antimicrobial agent. adj., adj microbici´dal.

mi·cro·bi·cide

(mī-krō'bi-sīd),
1. Synonym(s): microbicidal
2. An agent destructive to microbes; a germicide; an antiseptic.
[microbe + L. caedo, to kill]

mi·cro·bi·cide

(mī-krō'bi-sīd)
1. Synonym(s): microbicidal.
2. An agent destructive to microbes; a germicide; an antiseptic.
[microbe + L. caedo, to kill]

microbicide

Any agent capable of killing MICROBES. The term has, however, recently been applied specifically to any intravaginal, topical gel preparation for use by women to reduce their likelihood of acquiring HIV infection during sexual intercourse with husbands or others. The first candidate microbicide, nonoxynol-9, was shown to damage vaginal epithelial cells and actually encourage infection. Research for a safe and effective microbicide continues and includes the development of agents blocking CD4 binding sites, inhibitors of GP41-medicated fusion, prevention of HIV take up by dendritic cells and conventional pharmacological attack on HIV replication.

mi·cro·bi·cide

(mī-krō'bi-sīd)
Agent destructive to microbes; germicide; antiseptic.
[microbe + L. caedo, to kill]
References in periodicals archive ?
What Would Women Consider an Ideal Vaginal Microbicide?
The dapivirine ring was even more effective in women over 25, who saw their risk of HIV drop 61 percent while using the ring, developed by the nonprofit International Partnership for Microbicides (IPM).
In addition to microbicides, two long-acting injectable antiviral agents (rilpivirine and cabotegravir) are under development.
For now, all eyes on microbicide ring study results
Fauci was referring to a range of HIV prevention options that have been proven to work effectively such as: HIV testing and counselling, treatment as prevention, voluntary medical male circumcision (VMMC), treatment of STIs, rectal and vaginal microbicides (both are currently under research), prevention or treatment of drug and alcohol use, provision of clean needles and syringes, education, behaviour modification, male and female condoms, blood supply screening, antiretroviral drugs for prevention of mother to child transmission of HIV (PMTCT), Post-Exposure Prophylaxis (PEP), and Pre-Exposure Prophylaxis (PrEP).
Within one large microbicide trial in South Africa, Stadler and Saethre (2010) used indepth interviews with female participants and their partners, focus groups with community members, and participant observation in clinics to understand perceptions surrounding cash payments and reasons for collecting blood samples (40).
"A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV" PLoS ONE 9(4): e94547.
In 1999, the US government invested US $28 million (16) in microbicide research and development and more than $200 million in development of an HIV vaccine.
Vaginal microbicide gels are among an array of options including pills, rectal microbicides and vaginal rings that may one day help.
"If you go to a bar and ask how many people know what a microbicide is, most people won't raise their hand," Anton says.
The microbicide gel PRO2000 is safe, but does not prevent the vaginal transmission of HIV, according to a clinical trial conducted between September 2005 and August 2008 among adult sexually active, HIV-negative women from 13 clinics in four Sub-Saharan African countries.
An HIV prevention strategy that women can initiate or control in the form of a microbicide was first proposed almost two decades ago (14).