microbicide


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microbicide

 [mi-kro´bĭ-sīd]
an agent that destroys microbes; see also antimicrobial agent. adj., adj microbici´dal.

mi·cro·bi·cide

(mī-krō'bi-sīd),
1. Synonym(s): microbicidal
2. An agent destructive to microbes; a germicide; an antiseptic.
[microbe + L. caedo, to kill]

microbicide

/mi·cro·bi·cide/ (mi-kro´bĭ-sīd)
1. a substance that destroys microbes.
2. a substance that destroys infectious agents, including also viruses; sometimes used specifically for that used to prevent transmission of sexually transmitted diseases.microbici´dal

microbicide

[mīkrō′bisīd]
Etymology: Gk, mikros, small, bios, life; L, cadere, to kill
any drug, chemical, or other agent that can kill microorganisms.

mi·cro·bi·cide

(mī-krō'bi-sīd)
1. Synonym(s): microbicidal.
2. An agent destructive to microbes; a germicide; an antiseptic.
[microbe + L. caedo, to kill]

microbicide

Any agent capable of killing MICROBES. The term has, however, recently been applied specifically to any intravaginal, topical gel preparation for use by women to reduce their likelihood of acquiring HIV infection during sexual intercourse with husbands or others. The first candidate microbicide, nonoxynol-9, was shown to damage vaginal epithelial cells and actually encourage infection. Research for a safe and effective microbicide continues and includes the development of agents blocking CD4 binding sites, inhibitors of GP41-medicated fusion, prevention of HIV take up by dendritic cells and conventional pharmacological attack on HIV replication.

mi·cro·bi·cide

(mī-krō'bi-sīd)
Agent destructive to microbes; germicide; antiseptic.
[microbe + L. caedo, to kill]

microbicide

an agent that destroys microbes.
References in periodicals archive ?
For now, all eyes on microbicide ring study results
He stressed that developing different delivery systems for effective medications is an important step in ensuring the ultimate success of any microbicide, adding, "There is a growing demand for microbicides that prevent multiple STIs, and we are committed to ensuring that women and men have options when choosing what works most effectively for their own protection.
In the late 1980s, a few researchers began investigating the potential for Nonoxynol-9 (a widely-used spermicide) to function as a microbicide, a hypothesis ultimately rejected in 2000.
Another MTN017 rectal microbicide site in Thailand is in Chiang Mai, where the key researcher - Dr Suwat Chariyalertsak, Director, Research Institute for Health Sciences (RIHES), Chiang Mai University, Thailand - had received a global award in the past year for best retention of clinical study participants in the HPTN-052 study.
The CAPRISA 004 trial, the first trial to assess the effectiveness of a 1 per cent vaginal gel formulation of tenofovir as a potential microbicide, was a double-blind, randomized placebo-controlled trial which included 889 rural and urban South African women (ages 18 to 40 yr) who were sexually active and HIV-negative.
Recent studies have shown for the first time that a topical microbicide gel can protect women from HIV-1 infection.
Half of the women received the cream - the first microbicide to contain an antiretroviral drug commonly used to treat HIV-infected people - while the others used a placebo, a harmless but non-active lookalike.
It may become a less expensive new component of applied vaginal microbicides, according to new findings published in the Journal of Biological Chemistry .
The future of HIV prevention: prospects for an effective anti-HIV microbicide, Infectious Disease Clinics of North America, 2007, 21(1):219-239.
9m) to the Mintaka Foundation for Medical Research in Geneva, Switzerland, a not-for-profit foundation, to advance a low-cost anti-HIV microbicide into clinical trials.
Supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might help lower transmission rates of HIV, say researchers at San Francisco's Gladstone Institute of Virology and Immunology.
Mascolini: Why have microbicide candidates failed with such regularity?