noted that neutrophil depletion in the flaky skin (fsn)/fsn mutant mouse model of psoriasis-like lesion development contributed to a decrease in epidermal thickness, neutrophilic infiltrate, epidermal microabscesses
, and the number of CD3-positive T cells, thus to an improvement of psoriasiform skin lesions .
Initially, some prostate microabscesses
can appear and if they do not respond adequately to antibiotic treatment or if no treatment is started; this situation can lead to the onset of prostate abscesses of different dimensions.[sup.1] Such abscesses usually are complications of acute bacterial prostatitis that have either not been treated or been inappropriately treated.[sup.16] Although symptoms overlap with those of acute prostatitis, an abscess must be suspected when symptoms do not resolve after 48 hours of intravenous antibiotic therapy.
The K14-IL17A-ind/+ transgenic mouse represents an animal model of psoriasiform dermatitis characterized by deregulated, persistent overexpression of IL-17A in epidermal keratinocytes leading to prominent development of intraepidermal neutrophil microabscesses
in addition to dermal T-cell infiltration, hyperkeratosis, and parakeratosis .
formation with palisading histiocytes.
For example, a superficial diffuse dermal infiltrate with extensive epidermotropism and epidermal "microabscesses
" is most likely to be a T-cell lymphoid proliferation.
Lymphoid cells aligned along the basilar epidermis and entered the lower epidermis, with occasional, small, intraepidermal collections that resembled Pautrier microabscesses
. The lymphoid cells were predominantly small and displayed round to slightly irregular nuclear contours, mature chromatin, and pericellular haloes.
Hepatocyte degeneration, microabscess
focus, and capsular inflammation were graded by means of a semiquantitative evaluation .
It is characteristically associated with neutrophils within the parakeratotic plaque forming intraepithelial microabscess
. It does not exhibit basal atypia or abnormal keratinization.
Furthermore, when an SPE lesion develops into a microabscess
or a focal abscess, we can identify the responsible pathogen from BAL fluid collected from the abscessed lesion.
High-power images of the epidermis showed medium-sized lymphocytes with cerebriform nuclei arranged in Darier's nests (Pautrier's microabscess
) (figure 3a).
The final empirical results demonstrated that diagnosis on psoriasis vulgaris of Munro's microabscess
was highly sensitive and specific.
In addition, the MRI revealed multiple foci of restriction scattered throughout the liver and some of them showed subtle enhancement on postcontrast sequence suggestive of liver microabscess
(Figure 3).Constellation of MRI findings was suggestive of localized TB of the porta hepatis; however, neoplastic lesion such as rhabdomyosarcoma and lymphoma could not be excluded and further evaluation with a tissue biopsy was advised.