In 2013, Da-Zhi Wang, a cardiology researcher, identified a family of microRNAs
called miR-17-92 that regulates the proliferation of cardiomyocytes.
Such a key role is played by microRNAs
especially microRNA-192, microRNA-194 and microRNA-215 by molecular arrest of DNA replicative cycle; 2) Shortening of Telomeres: Similarly, microRNAs
such as microRNA-34, microRNA-138 and microRNA-155 are linked with maintenance of telomere length; to avoid premature 'telomere crisis' and aging; 3) Epigenetic Regulation: A cocktail of microRNAs
have also been associated with epigenetic regulation of aging; by histone modification (microRNA-15a, microRNA-16 and microRNA-29) and splicing (microRNA-519, microRNA-16 and microRNA-125a); 4) Proteostasis: Deregulation of protein homeostasis leads to abnormal protein aggregation within cell.
They identified a number of microRNAs
that change in the bone marrow stem cells with aging and we are going after each one of these to understand how they are working and are they working together or independently.
The aim of this preliminary study based on a small cohort of ONIHL was to compare the serum expression profiles of microRNAs
between ONIHL subjects and controls using microRNA
The let-7 microRNAs
are noncoding RNAs which consist of ~22 nucleotides .
Huang, "Biomarker micrornas
for diagnosis of oral squamous cell carcinoma identified based on gene expression data and microrna-mrna network analysis," Computational and Mathematical Methods in Medicine, vol.
: target recognition and regulatory functions," Cell, vol.
In this review, we aim at providing an overview of recent advances in the characterization of extracellular (plasma/ serum) microRNAs
Given that the pathogenesis of some diseases involves under or overexpression of microRNAs
(Table 1), the evaluation of microRNA
expression may be used in therapeutic planning.
Genomic diagnostics company Rosetta Genomics Ltd (NasdaqCM;ROSG) reported on Monday the receipt of two patent allowances in the US from the US Patents and Trademark Office (USPTO) under the parent application titled "microRNAs
and uses thereof " in the field of thyroid cancer.
Steitz, "EBV and human microRNAs
co-target oncogenic and apoptotic viral and human genes during latency," The EMBO Journal, vol.