microRNAs


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microRNAs

Small lengths of RNA encoded by their own family of genes located either in non-coding regions of the genome or in the introns of protein-coding genes. MicroRNAs are an integral part of the genetic program and are believed to control gene expression by inhibiting messenger RNAs. Some may act as oncogenes and some may be tumour suppressors. It is thought that the human genome may contain as many as 1000 genes for microRNAs.
References in periodicals archive ?
In 2013, Da-Zhi Wang, a cardiology researcher, identified a family of microRNAs called miR-17-92 that regulates the proliferation of cardiomyocytes.
Such a key role is played by microRNAs especially microRNA-192, microRNA-194 and microRNA-215 by molecular arrest of DNA replicative cycle; 2) Shortening of Telomeres: Similarly, microRNAs such as microRNA-34, microRNA-138 and microRNA-155 are linked with maintenance of telomere length; to avoid premature 'telomere crisis' and aging; 3) Epigenetic Regulation: A cocktail of microRNAs have also been associated with epigenetic regulation of aging; by histone modification (microRNA-15a, microRNA-16 and microRNA-29) and splicing (microRNA-519, microRNA-16 and microRNA-125a); 4) Proteostasis: Deregulation of protein homeostasis leads to abnormal protein aggregation within cell.
They identified a number of microRNAs that change in the bone marrow stem cells with aging and we are going after each one of these to understand how they are working and are they working together or independently.
The aim of this preliminary study based on a small cohort of ONIHL was to compare the serum expression profiles of microRNAs between ONIHL subjects and controls using microRNA microarray assay.
The let-7 microRNAs are noncoding RNAs which consist of ~22 nucleotides [5].
Huang, "Biomarker micrornas for diagnosis of oral squamous cell carcinoma identified based on gene expression data and microrna-mrna network analysis," Computational and Mathematical Methods in Medicine, vol.
In this review, we aim at providing an overview of recent advances in the characterization of extracellular (plasma/ serum) microRNAs in GDM.
Given that the pathogenesis of some diseases involves under or overexpression of microRNAs (Table 1), the evaluation of microRNA expression may be used in therapeutic planning.
Genomic diagnostics company Rosetta Genomics Ltd (NasdaqCM;ROSG) reported on Monday the receipt of two patent allowances in the US from the US Patents and Trademark Office (USPTO) under the parent application titled "microRNAs and uses thereof " in the field of thyroid cancer.
Steitz, "EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency," The EMBO Journal, vol.