microRNA


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microRNA

(mī′krō-är′ĕn′ā′)
n. Abbr. miRNA
Any of various short, single-stranded RNA molecules that regulate gene expression by binding to messenger RNA molecules, usually in untranslated regions.

microRNA

Any of a group of short (generally 21 to 24 nucleotides in length), non-coding RNA molecules which fold upon themselves (“hairpins”) and are usually cleaved from larger hairpin-containing RNA (itself often processed from some portion of mRNA).

MiRNA is conserved through evolution and plays a role in RNA interference, destroying mRNA made by specific genes, suppressing gene expression and controlling translation of target mRNAs, thereby regulating critical aspects of plant and animal development.

microRNA

(mī′krō-ăr′ĕn″ā″) [″ + ″],

miRNA

Oligonucleotides that prevent a variety of messenger RNAs from being transcribed from DNA or translated into proteins. They typically consist of 21 to 25 linked nucleotides.

microRNA

Very short segments of RNA involved in RNA INTERFERENCE and recently shown to be important elements in the development of plant structure. Many genes that code for microRNA have been found in many species including H. sapiens . There is much current speculation into their role in human development.
References in periodicals archive ?
November 15, 2017 -- Scientists here have partly solved a long-unanswered basic question about stem cells: Why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate?
Several cardiac biomarkers have already been shown to be useful in the evaluation of a variety of diseases (BOSWOOD, 2009) and, similarly, the evaluation of microRNA expression in heart diseases may well provide a noninvasive technique for gathering information to aid diagnosis and prognosis which could lead to the development of new therapeutic protocols.
RosettaGX Reveal, a Thyroid microRNA Classifier for the diagnosis of cancer in thyroid nodules, as well as the full RosettaGX portfolio of cancer testing services are commercially available through the company's Philadelphia, PA- and Lake Forest, CA-based CAP-accredited, CLIA-certified labs.
The aspects of the microRNA market - research, diagnostics, and therapeutics - all hold major importance in various areas of the healthcare and pharmaceutical industries.
The specific set of blood microRNA that the Otago researchers had identified could detect Alzheimer's disease correctly 86 percent of the time.
If the findings hold up, microRNAs may become a tool for shaping the composition of the body's microbes, or microbiome.
The biomarkers are microRNAs, small strands of genetic material that are able to switch off genes by interfering with the way their codes are translated.
This suggests that we may be able to track the presence of papillary thyroid cancer by a microRNA blood test," said Lee.
Exiqon's microRNA PCR product line is being used for microRNA expression profiling in a variety of sample types including difficult samples like blood serum and FFPE.
5%) of the circulating microRNAs reported by the authors originated from a region on chromosome 19 known to contain a large cluster of microRNA genes and other genomic elements involved in placental growth and development (8).
The study, which appears in Nature points to an alternative pathway of microRNA generation that the team discovered by analyzing a microRNA molecule produced in developing red blood cells.
The company's scientists and collaborators have identified microRNA biomarkers in serum, which have the potential to accurately differentiate colorectal cancer patients from healthy individuals.