microRNA


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microRNA

(mī′krō-är′ĕn′ā′)
n. Abbr. miRNA
Any of various short, single-stranded RNA molecules that regulate gene expression by binding to messenger RNA molecules, usually in untranslated regions.

microRNA

Any of a group of short (generally 21 to 24 nucleotides in length), non-coding RNA molecules which fold upon themselves (“hairpins”) and are usually cleaved from larger hairpin-containing RNA (itself often processed from some portion of mRNA).

MiRNA is conserved through evolution and plays a role in RNA interference, destroying mRNA made by specific genes, suppressing gene expression and controlling translation of target mRNAs, thereby regulating critical aspects of plant and animal development.

microRNA

(mī′krō-ăr′ĕn″ā″) [″ + ″],

miRNA

Oligonucleotides that prevent a variety of messenger RNAs from being transcribed from DNA or translated into proteins. They typically consist of 21 to 25 linked nucleotides.

microRNA

Very short segments of RNA involved in RNA INTERFERENCE and recently shown to be important elements in the development of plant structure. Many genes that code for microRNA have been found in many species including H. sapiens . There is much current speculation into their role in human development.
References in periodicals archive ?
Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits.
They identified a number of microRNAs that change in the bone marrow stem cells with aging and we are going after each one of these to understand how they are working and are they working together or independently.
INT-1B3 is a lipid nanoparticle formulated, chemically modified microRNA 193a-3p mimic that can be delivered systemically to cancer cells.
On the next day, cells were co-transfected with 3' UTR luciferase plasmid (0.1 mg), microRNA plasmid (0.4 mg) and Renilla plasmid (0.02 mg) using X-tremeGENE HP DNA Transfection Reagent (Roche).
Hammond, "Lin28 interaction with the Let-7 precursor loop mediates regulated microRNA processing," RNA, vol.
Shamir, "Towards computational prediction of microRNA function and activity," Nucleic Acids Research, vol.
Since the discovery of extracellular microRNAs in 2008 [27], researchers identified multiple mechanisms of microRNA transport, derived from different cell secretion/release pathways [28]:
MicroRNA mimics can be used to treat diseases where there is subexpression microRNAs.
RosettaGX Reveal, a Thyroid microRNA Classifier for the diagnosis of cancer in thyroid nodules, as well as the full RosettaGX portfolio of cancer testing services are commercially available through the company's Philadelphia, PA- and Lake Forest, CA-based CAP-accredited, CLIA-certified labs.
The author has chosen to focus upon a particular class of viral-encoded microRNA termed BART because these transcripts are not only expressed in latently infected cells but also found in noninfected cells as will be discussed later in more detail [5, 6].