mibefradil


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mibefradil

A calcium-channel blocker that vasodilates without reflex tachycardia, which was used to manage hypertension or chronic stable angina. It was pulled from the market due to its inhibition of the liver metabolism of certain drugs (e.g., antihistamines) and statins, and increased mortality in patients with congestive heart failure.

mibefradil

Posicor® Cardiology A CCB that vasodilates without reflex tachycardia, used to manage HTN and angina pectoris; it was pulled from the market as it inhibits liver metabolism of certain drugs–eg, antihistamine, Histamal, and statin cholesterol-lowering agents. See Calcium channel blocker.
References in periodicals archive ?
T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines.
ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, etc.
Sodium hydrosulfide hydrate (NaHS), EGTA, thapsigargin (TG), nifedipine, nimodipine, and mibefradil were obtained from Sigma-Aldrich.
Anti-adhering and anti-migratory compounds ilomastat (a matrix metalloproteinase inhibitor), naphtyl urea suramin, [44] salmosin (a disintegrin), [45] mibefradil (Ca- channel inhibitor), [46] RGD peptide, EDTA, [47] and coating an acrylic IOL surface with MPC polymer; [48]
Antineoplasicos: doxorrubicina, paclitaxel, docetaxel, etoposido, imatinib, teniposido, vincristina, vinblastina, mitoxantrona, actinomicina D Manejo cardiovascular: digoxina, bunitrolol, carvedilol, celiprolol, talinolol, diltiazem, mibefradil, verapamilo, digitoxina, quinidina, atorvastatina, lovastatina, losartan.
Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction.
lacidipine, lercanidipine, manidipine, mibefradil nicardipine,
3 November 2011 - US drug discovery and development firm SCYNEXIS Inc said on Wednesday it had developed an innovative API synthetic process for mibefradil in partnership with clinical-stage biopharmaceutical firm TAU Therapeutics and consulting and project management expert PharmaDirections Inc.
Incluso, despues de haber sido lanzados al mercado, algunos medicamentos debieron ser retirados por toxicidad inesperada, como ocurrio hace algunos anos con astemizol, terfenadina, fenfluramina y mibefradil.
Sildenafilin klirensini uzatan ilaglar Amiodarone Cerivasatin Atorvastatin Disopyramide Digitoxin Simvastatin Losartan Quinidine Felodidine Verapamil Lovastatin Mibefradil Diltiazem Isradipine Nifedipine
Their study found that mibefradil had the same effect as the dihydropyridines in lowering blood pressure, yet with lower fluid filtration, suggesting that mibefradil is not as harmful to vascular permeability in hypertensive rats as dihydropyridines.
The Prescription Drug User Fee Act and FDAMA provisions have had positive effects on accelerated development and expanded access, but several drugs were withdrawn from the market after the new laws (eg, mibefradil, dexfenfluramine, terfenadine, bromfenac, and troglitazone) and debate ensued.