mevalonic acid


Also found in: Encyclopedia, Wikipedia.

mev·a·lon·ic ac·id

(mev'ă-lon'ik as'id),
Precursor of squalene, steroids, terpenes, and dolichol.

mevalonic acid

A molecular precursor of endogenous biomolecules formed in the mevalonate pathway, which produces terpenes and steroids (e.g., cholesterol, coenzyme Q and carotenoids).

mevalonic acid

A molecular precursor of many endogenous molecules–eg, cholesterol, coenzyme Q, carotenoids, dolichol, steroids, and terpenes
References in periodicals archive ?
Since GA3 derived from mevalonic acid similarly to a juvenile hormone (JH), Uckan et al.
Abrogation of insulinlike growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways.
Diagnosis is based on genetic testing and elevated mevalonic acid levels in urine.
Lupeol and sitosterol are distributed in plant kingdom, which their biosynthesis is via the mevalonic acid pathway.
(5) During attacks, urinary excretion of mevalonic acid increases, and measurements have diagnostic value.
They are mainly synthesized by polymalonate, shikimic acid and mevalonic acid pathways (Boustie and Grube, 2005).
They can even be moieties of central metabolites, such as citric and mevalonic acid, which are processed by nearly universal metabolic pathways.
Some precursors such as sodium acetate, mevalonic acid lactone, casein acid hydrolysate have been investigated to enhance yield of ART in plant and cell cultures of A.
Also known as hyperimmunoglobulinemia D syndrome, MKD (OMIM 260920) is an autosomal recessive disease caused by mutations in the MVK gene [102](Table 1), encoding for the enzyme mevalonate kinase, involved in the ATP-dependent phosphorylation of mevalonic acid into 5-phosphomevalonate.
(2004), the deficiency of P in the vegetable tissue of a plant may reduce the phosphorylation of mevalonic acid, which means the initial step for the synthesis of isopentenyl pyrophosphate, through the classical route of mevalonate synthesised from acetyl coenzyme A, the main precursor of monoterpenes, such as citral and limonene (Bruneton, 1991; Lange et al., 1998).
They are usually synthesized in the leaves, stored in extracellular spaces between the cuticle and the cell wall, and basically constituted by terpenes, synthesized by the mevalonic acid route.
Also identified was a strong signal suggesting interaction between host ?d T cells and genes in the GAS mevalonic acid synthesis pathway responsible for production of isopentenyl-pyrophosphate, a short-chain phospholipid that stimulates these T-cells.