The overnight metyrapone
test should be used to make the definitive diagnosis of HPAS.
Other case reports have described usage of metyrapone
, etomidate, mitotane, and mifepristone as steroidogenesis inhibitors .
, etomidate, mitotane, and mifepristone can be used to reduce the circulating cortisol level.
Comparison of overnight metyrapone
test to either low-dose or high-dose ACTH test," Hormone Research, vol.
Successful medical treatment using metyrapone
or ketoconazol has been reported during pregnancy.
Researchers and specialty pharmaceutical company Embera NeuroTherapeutics, Inc., have been examining the link between stress and addiction as they study whether a combination of the benzodiazepine oxazepam and the Cortisol synthesis inhibitor metyrapone
could become the breakthrough drug for cocaine dependence.
Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone
test in the diagnosis of adrenal insufficiency in childhood.
Legutko, "Combined treatment with imipramine and metyrapone
induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats," Pharmacological Reports, vol.
In the management of Cushing syndrome, cortisol concentrations are used to help guide the appropriate dosing of metyrapone
, a potent 11[beta]-hydroxylase inhibitor (6).
Pioneering research by mood disorder specialists at Newcastle University has questioned the effectiveness of metyrapone
, a drug suggested to treat depression.
By increasing the plasma ACTH concentration by administration of ACTH or metyrapone
, an inhibitor for glucocorticoid biosynthesis, the rhythm of cell replication was found to shift accordingly.
Central serotonergic responses and behavioral adaptation to repeated immobilization: the effect of the corticosterone synthesis inhibitor metyrapone