metyrapone


Also found in: Wikipedia.

metyrapone

 [mĕ-tēr´ah-pōn]
a synthetic compound that selectively inhibits an enzyme responsible for the biosynthesis of corticosteroids; it is used as a diagnostic aid in a test of pituitary reserve.

me·tyr·a·pone

(mĕ-tir'ă-pōn),
An inhibitor of adrenocortical steroid C-11 β-hydroxylation, administered orally or intravenously to determine the ability of the pituitary gland to increase its secretion of corticotropin; because 11-deoxycorticosteroids, as a consequence of metyrapone administration, only weakly inhibit pituitary corticotropin secretion, the normal pituitary gland will appreciably increase its output of this hormone.
Synonym(s): mepyrapone

metyrapone

An agent used to evaluate the hypothalamus-pituitary-adrenal axis, especially abnormal pituitary activity. Metyrapone inhibits 11-beta-hydroxylase, the final enzyme in cortisol synthesis. The inhibition results in accumulation of 11-deoxycortisol in the adrenal cortex, resulting in decreased negative feedback of ACTH synthesis by the pituitary; it therefore also results in increased ACTH and increased 11-deoxycortisol, as well as its metabolite, tetrahydrocortisol, which is measured in the urine as so-called Porter-Silber compounds.

metyrapone

A diagnostic tool for evaluating the hypothalamus-pituitary-adrenal 'axis', especially, abnormal pituitary activity

metyrapone

An ALDOSTERONE inhibitor drug used to treat aldosterone-induced OEDEMA and CUSHING'S syndrome. A brand name is Metopirone.
References in periodicals archive ?
The overnight metyrapone test should be used to make the definitive diagnosis of HPAS.
Other case reports have described usage of metyrapone, etomidate, mitotane, and mifepristone as steroidogenesis inhibitors [8].
Ketoconazole, metyrapone, etomidate, mitotane, and mifepristone can be used to reduce the circulating cortisol level.
Comparison of overnight metyrapone test to either low-dose or high-dose ACTH test," Hormone Research, vol.
Successful medical treatment using metyrapone or ketoconazol has been reported during pregnancy.
Researchers and specialty pharmaceutical company Embera NeuroTherapeutics, Inc., have been examining the link between stress and addiction as they study whether a combination of the benzodiazepine oxazepam and the Cortisol synthesis inhibitor metyrapone could become the breakthrough drug for cocaine dependence.
Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood.
Legutko, "Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats," Pharmacological Reports, vol.
In the management of Cushing syndrome, cortisol concentrations are used to help guide the appropriate dosing of metyrapone, a potent 11[beta]-hydroxylase inhibitor (6).
Pioneering research by mood disorder specialists at Newcastle University has questioned the effectiveness of metyrapone, a drug suggested to treat depression.
By increasing the plasma ACTH concentration by administration of ACTH or metyrapone, an inhibitor for glucocorticoid biosynthesis, the rhythm of cell replication was found to shift accordingly.
Central serotonergic responses and behavioral adaptation to repeated immobilization: the effect of the corticosterone synthesis inhibitor metyrapone. Eur.