mansoni infection (contraindicated in pregnancy) and metrifonate
as an alternative for S.
A randomized, controlled trial trying to assess the clinical efficacy of topical ivermectin, thiabendazole and metrifonate
for the treatment of tungiasis showed that each of them can significantly reduce the number of lesions caused by embedded sand flies seven days after starting treatment, as compared with the non-treated and placebo groups (10).
haematobium-infected children were randomly assigned to groups for treatment with either praziquantel (Biltricide, Bayer, Leverkusen, Germany), 40 mg/kg once a year, or metrifonate
(Bilarcil, Bayer), 10 mg/kg three times a year.
He looked at physostigmine, tacrine, donepezil, metrifonate
, eptastigmine, and rivastigmine.
In fact a related compound, metrifonate
, is a potential treatment but tests on it were halted after patients suffered "muscle weakness and breathing difficulties".
The drug, Metrifonate
, doesn't stop the brain cells from continuing to die, but it does make the ones that are remaining work twice as hard.
GOOD news for carers of people with Alzheimer's disease - metrifonate
, which started life years ago as a treatment for tropical liver fluke disease, has shown excellent results in early Alzheimer's.
However tacrine should be used as a benchmark for the evaluation of other aminoacridines such as donepezil, galantamine and metrifonate
as anti-dementia drugs.
, which has been used to treat tropical infections, is set to revolutionise dementia therapy, while Exelon is designed specifically for Alzheimer's.
Presently, the allopathic system of medicine principally relies on nootropic agents, such as piracetam, aniracetam, fosracetam, nefiracetam, etc., and anticholinesterases, such as donepezil, metrifonate
, rivastigmine, etc.
Other cholinesterase inhibitors in the developmental pipeline include metrifonate
, an irreversible inhibitor of cholinesterase, and rivastigmine, whose marketing application is under review at the Food and Drug Administration, he said.
, another cholinesterase inhibitor that has shown promise in clinical trials, can reduce hallucinations, apathy, and aberrant movements associated with Alzheimer's.