methysergide


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methysergide

 [meth″ĭ-ser´jīd]
a potent serotonin antagonist and vasoconstrictor, used in the prophylaxis of migraine; also available as the maleate salt.

methysergide

A SEROTONIN antagonist ERGOT derivative drug used to treat resistant cases of MIGRAINE and some cases of persistent diarrhoea. A brand name is Deseril.
References in periodicals archive ?
Methysergide (Sansert) is contraindicated but is not available in United States.
Les principales causes de la FRP secondaire (1) Medicaments Methysergide Pergolide Bromocriptine Ergotamine Methyldopa Hydralazine Analgesiques Beta-bloquants Tumeurs malignes Tumeurs carcinoides Lymphomes Hodgkiniens et non Hodgkiniens Sarcomes Cancers : colon, prostate, poumon, estomac Infections Tuberculose Histoplasmose Actinomycose Radiotherapie Seminome testiculaire Carcinome du colon Carcinome pancreatique Chirurgie Lymphadenectomie Colectomie Hysterectomie Anevrysectomie aortique Autres Histiocytose Maladie de l'Erdheim-Chester Amylose Traumatismes Lavement baryte Tableau 2.
Non-specific binding was assessed by adding 10 [micro]M of methysergide.
* drugs (ergot derivatives, methysergide, bromocriptine, ,[beta]-blockers, methyldopa and hydralazine)
Schousboe, "Serotonin receptors on astrocytes in primary cultures: effects of methysergide and fluoxetine," Canadian Journal of Physiology and Pharmacology, vol.
The 5-HT receptor antagonist methysergide inhibited the influence of 5-HT on the overall amount of swimming but not on swimming speed.
PH icin celecoxib (59), rofecoxib (60), asetilsalisilik asit (61), verapamil (61,62,63), acetozolamide (58) topiramate (64,65), steroidler (66) ve buyuk oksipital sinir blokajinin (67) etkili oldugunu bildiren vaka calismalari; HC icin ibuprofen (68), piroxicam (69,70), naproxen (71), rofecoxib (72), celecoxib (73) topiramate (74), gabapentin (75), methysergide, glukokortikoidler, buyuk oksipital sinir blokaji (76), melatonin (77,78), verapamil'in (79) etkili oldugunu bildiren olgular mevcut olsa da; indomethacin kadar tutarli yanit alinan baska bir ajan daha mevcut degildir.
This phenomenon corresponds with other studies, which have found that adrenalectomy interferes with increases in glucagon-induced plasma glucose provoked by intravenous administration of 5-HT.35 Finally, the fact that methysergide, a 5-HT antagonist, can prevent the effects of glucagon provides additional support for the postulation that serotonin, acting at the islet cells directly, is the factor responsible for the above phenomenon.
Case reports also suggest using serotonin receptor antagonists--such as cyproheptadine, methysergide, chlorpromazine, or propranolol--to clinically manage serotonin syndrome, although empiric support is limited.(9)
"Clearly, practitioners should avoid prescribing drugs that are potent 5-H[T.sub.2B]-receptor agonists--a growing list of medications that now includes ergot derivatives (ergotamine, methysergide, and dihydroergotamine), dopamine agonists (pergolide and cabergoline), and amphetamine derivatives (fenfluramine and methylenedioxymethamphetamine [MDMA, or 'ecstasy'])," Dr.
* methysergide maleate, which counteracts blood vessel constriction