methyltransferase


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methyltransferase

 [meth″il-trans´fer-ās]
any enzyme that catalyzes transmethylation.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

meth·yl·trans·fer·ase

(meth'il-trans'fer-ās),
Any enzyme transferring methyl groups from one compound to another.
Farlex Partner Medical Dictionary © Farlex 2012

meth·yl·trans·fer·ase

(meth'il-trans'fĕr-ās)
Any enzyme transferring methyl groups from one compound to another.
Synonym(s): transmethylase.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
(2003) reported that cadmium exposure of non transformed rat cells resulted in the inhibition of methyltransferase activity and, at higher exposures, hypomethylation.
(18) Alteration in DNA methyltransferases plays an important role in the development of cancer.
Specific enzymes, the DNA methyltransferases, are responsible for methylation.
Thiopurine methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including mercaptopurine (MP), thioguanine (TG), and azathioprine (AZA) (1).
Knowing a patient's RBC thiopurine methyltransferase (TPMT) activity is useful in individualizing the dosing of these potent steroid-sparing immunosuppressant therapies, said Dr.
(32.) Otterness D, Szumlanski C, Lennard L, Klemetsdal B, Aarbakke J, Park-Hah JO, Iven H, Schmiegelow K, Branum E, O'Brien J, Weinshilboum R: Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms.
The authors discovered that the molecule Suv4-20h2, a so-called histone methyltransferase, travels over the chromatin and attaches small chemical changes (dubbed methyl groups) to the histones.
9,120,820, claims detection analyte probes based on a natural product mimic of the methyltransferase cofactor S-adenosylmethionine (SAM).
pneumoniae, the unusually high level of resistance to amikacin (MIC > 32 [micro]g/mL) and gentamicin (MIC > 8 [micro]g/mL) increased concern for presence of an NDM-1 producer, which is frequently highly resistant to aminoglycosides because of production of 16S rRNA methyltransferase (8).
Under conditions that were suitable for the in vitro enzymatic methylation of DNA and dietary catechols, we found that the presence of caffeic acid or chlorogenic acid inhibited in a concentration-dependent manner the DNA methylation catalyzed by prokaryotic M.SssI DNA methyltransferase (DNMT) and human DNMT1.
An enzyme called thiopurine methyltransferase, or TPMT, normally inactivates the drugs.