(2003) reported that cadmium exposure of non transformed rat cells resulted in the inhibition of methyltransferase
activity and, at higher exposures, hypomethylation.
(18) Alteration in DNA methyltransferases
plays an important role in the development of cancer.
Specific enzymes, the DNA methyltransferases
, are responsible for methylation.
(TPMT) is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including mercaptopurine (MP), thioguanine (TG), and azathioprine (AZA) (1).
Knowing a patient's RBC thiopurine methyltransferase
(TPMT) activity is useful in individualizing the dosing of these potent steroid-sparing immunosuppressant therapies, said Dr.
(32.) Otterness D, Szumlanski C, Lennard L, Klemetsdal B, Aarbakke J, Park-Hah JO, Iven H, Schmiegelow K, Branum E, O'Brien J, Weinshilboum R: Human thiopurine methyltransferase
pharmacogenetics: Gene sequence polymorphisms.
The authors discovered that the molecule Suv4-20h2, a so-called histone methyltransferase
, travels over the chromatin and attaches small chemical changes (dubbed methyl groups) to the histones.
9,120,820, claims detection analyte probes based on a natural product mimic of the methyltransferase
cofactor S-adenosylmethionine (SAM).
pneumoniae, the unusually high level of resistance to amikacin (MIC > 32 [micro]g/mL) and gentamicin (MIC > 8 [micro]g/mL) increased concern for presence of an NDM-1 producer, which is frequently highly resistant to aminoglycosides because of production of 16S rRNA methyltransferase
Under conditions that were suitable for the in vitro enzymatic methylation of DNA and dietary catechols, we found that the presence of caffeic acid or chlorogenic acid inhibited in a concentration-dependent manner the DNA methylation catalyzed by prokaryotic M.SssI DNA methyltransferase
(DNMT) and human DNMT1.
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase
, and histamine N-methyltransferase.
An enzyme called thiopurine methyltransferase
, or TPMT, normally inactivates the drugs.