methylergonovine maleate

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methylergonovine maleate


Pharmacologic class: Ergot alkaloid

Therapeutic class: Oxytocic

Pregnancy risk category C


Directly stimulates vascular smooth-muscle contractions in uterus and cervix and decreases bleeding after delivery


Injection: 0.2 mg/ml

Tablets: 0.2 mg

Indications and dosages

Prevention and treatment of postpartum hemorrhage

Adults: 0.2 mg I.M.; repeat q 2 to 4 hours as needed to a total of five doses. In emergencies, 0.2 mg I.V. over 1 minute. After initial I.M. or I.V. dose, 0.2 mg P.O. q 6 to 8 hours for 2 to 7 days; decrease dosage if cramping occurs.


• Hypersensitivity to drug

• Hypertension

• Toxemia

• Pregnancy (except during third stage of labor)


Use cautiously in:

• severe hepatic or renal disease, vascular disease, jaundice, sepsis

• patients in second stage of labor.


• Be aware that drug isn't routinely given I.V. because of risk of severe hypertension and cerebrovascular accident (CVA). Monitor blood pressure and uterine contractions during administration.

• If I.V. use is necessary, give dose over 1 minute. Dose may be diluted in 5 ml of 0.9% sodium chloride injection.

• Be aware that prolonged therapy should be avoided because of ergotism risk.

Adverse reactions

CNS: dizziness, headache, hallucination, seizures, CVA (with I.V. use)

CV: hypertension, hypotension, transient chest pain, palpitations, thrombophlebitis

EENT: tinnitus, nasal congestion

GI: nausea, vomiting, diarrhea

GU: hematuria

Musculoskeletal: leg cramps

Respiratory: dyspnea

Skin: diaphoresis, rash, allergic reactions

Other: foul taste


Drug-drug. Dopamine, ergot alkaloids, oxytocin, regional anesthetics, vasoconstrictors: excessive vasoconstriction

Drug-diagnostic tests. Prolactin: increased level

Patient monitoring

Know that if used during third stage of labor, drug increases risk of hemorrhage and infection.

• When giving I.V., closely monitor blood pressure, pulse, uterine contractions, and bleeding.

• Monitor patient for adverse effects.

Patient teaching

• Inform patient and family of reason for using drug, and provide reassurance.

• Tell patient drug may cause nausea, vomiting, dizziness, increased blood pressure, headache, ringing in ears, chest pain, or shortness of breath. Advise her to report severe or troublesome symptoms.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved
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References in periodicals archive ?
In addition, the company plans to market the approved generic version of Methergine Tablets USP, 0.2 mg (Methylergonovine Maleate Tablets USP, 0.2 mg ) shortly.
Methylergonovine maleate is also available as an intramuscular injection.
They received medical treatment (methylergonovine maleate, misoprostol, or high-dose estrogen depending on the presumed diagnosis of either retained products or dysfunctional bleeding), and if this treatment was not successful, then surgical intervention was the next step.
She is given 40 U of oxytocin in 1 L of lactated Ringer solution, two intramuscular doses of 0.2 mg of methylergonovine maleate, and 1,000 [micro]g of misoprostol to treat the postpartum bleeding.
The hemorrhage was controlled with uterine message, intravenous oxytocin, and oral methylergonovine maleate.