methylcytosine

[meth″il-si´to-sin]

a pyrimidine occurring in deoxyribonucleic acid.

methylcytosine

(mĕth″ĭl-sī′tō-sĭn)

A derivative of pyrimidine present in some nucleic acids.

References in periodicals archive ?

TET2 Mutation: The somatic methylcytosine dioxygenase "ten-eleven translocation 2" (TET2) mutations occur in approximately 23% of AML cases (34).

Navigating through Mutations in Acute Myeloid Leukemia. What Do We Know and What Do We Do with It?

5 methylcytosine performs similar functions as that of normal cytosine.

Epigenetic Alterations and their Dietary Backgrounds

Rao, "TET methylcytosine oxidases in T cell and B cell development and function," Frontiers in Immunology, vol.

Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

The total methylcytosine level can be assessed by chromatographic methods to determine the global methylated levels.

DNA Methylation Status of the Interspersed Repetitive Sequences for LINE-1, Alu, HERV-E, and HERV-K in Trabeculectomy Specimens from Glaucoma Eyes

Wang et al., "The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells," Immunity, vol.

STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in [CD4.sup.+] T Cells of Patients with Colorectal Cancer

Chang et al., "Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells," Proceedings of the National Academy of Sciences of the United States of America, vol.

The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation

The TET2 gene encodes a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine.

Jumping Translocations of 1q in Myelodysplastic Syndrome and Acute Myeloid Leukemia: Report of Three Cases and Review of Literature

TET2 gene located on chromosome 4q24 codes for an enzyme that converts methylcytosine to 5-hydroxymethylcytosine (5hmc) required for normal DNA activation.

Recent advances in diagnostic and prognostic aspects of acute myeloid leukaemia

These authors suggested that the differences in DNA methylation could reflect different developmental processes occurring in the plant cells, similar to animal embryos, in which a wave of demethylation following fertilization leads to an almost complete conversion of methylcytosine to cytosines (Chakrabarty et al., 2003).

Dynamics in global DNA methylation and endogenous polyamine levels during protocorm-like bodies induction of Cattleya tigrina A. Richard/Dinamica da metilacao do DNA global e niveis endogenos de poliaminas durante a inducao de estruturas semelhantes a protocormos de Cattleya tigrina A. Richard

Previous studies have shown that cytosine can exist in two forms, one of which is the methylated version methylcytosine. Since the methylation of cytosine does not alter the DNA sequence, but only influences when and where these proteins are produced, it is considered an epigenetic modification.

Scientists Study How Epigenetic Changes Are Read And Interpreted

Set of proteins known as ten-eleven translocation (Tet1-3) demethylates methylcytosine via hydroxymethylcytosine (hmC) [9].

New Insights into the Epigenetics of Hepatocellular Carcinoma

Based on our previous experience [26,27], we performed CE separation of cytosine and methylcytosine by using a run buffer of TRIS phosphate at low pH in a 100 [micro]m id uncoated capillary starting from only 2 [micro]g of DNA.

Evaluation of Global Genomic DNA Methylation in Human Whole Blood by Capillary Electrophoresis UV Detection