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Related to methylcellulose: Hydroxypropyl methylcellulose


a methyl ester of cellulose, used as a bulk laxative, as a suspending agent for drugs, and applied topically to the cornea during certain ophthalmic procedures to protect and lubricate the cornea.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Celevac (UK), Citrucel, Entrocel (CA)

Pharmacologic class: Semisynthetic cellulose derivative

Therapeutic class: Bulk laxative

Pregnancy risk category NR


Stimulates peristalsis by promoting water absorption into fecal matter and increasing bulk, resulting in bowel evacuation


Powder: 105 mg/g, 196 mg/g

Indications and dosages

Chronic constipation

Adults and children ages 12 and older: Up to 6 g P.O. daily in divided doses of 0.45 to 3 g

Children ages 6 to 11: Up to 3 g P.O. daily in divided doses of 0.45 to 1.5 g


• Signs or symptoms of appendicitis or undiagnosed abdominal pain

• Partial bowel obstruction

• Dysphagia


Use cautiously in:

• hepatitis

• intestinal ulcers

• laxative-dependent patients.


• Give with 8 oz of fluid.

• If patient is receiving maximum daily dosage, give in divided doses to reduce risk of esophageal obstruction.

Adverse reactions

GI: nausea; vomiting; diarrhea; severe constipation; abdominal distention; cramps; esophageal, gastric, small-intestine, or colonic strictures (with dry form); GI obstruction

Other: laxative dependence (with long-term use)


Drug-drug. Antibiotics, digitalis, nitrofurantoin, oral anticoagulants, salicylates, tetracyclines: decreased absorption and action of these drugs

Patient monitoring

• Assess patient's dietary habits. Consider factors that promote constipation, such as certain diseases and medications.

• Monitor patient for signs and symptoms of esophageal obstruction.

• Evaluate fluid and electrolyte balance in patients using laxatives excessively.

Patient teaching

• Instruct patient to take with a full glass (8 oz) of water.

• Advise patient to prevent or minimize constipation through adequate fluid intake (four to six glasses of water daily), proper diet, increased fiber intake, daily exercise, and prompt response to urge to defecate.

Instruct patient to report chest pain or pressure, vomiting, and difficulty breathing (possible symptoms of GI obstruction).

• Caution patient not to use drug for more than 1 week without prescriber's approval.

• Inform patient that chronic laxative use may lead to dependence.

• Tell patient to contact prescriber if constipation persists or if rectal bleeding or symptoms of electrolyte imbalance (muscle cramps, weakness, dizziness) occur.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A methyl ester of cellulose that forms a colorless viscous liquid when dissolved in water, alcohol, or ether; used to increase bulk of the intestinal contents, to relieve constipation, or of the gastric contents, to reduce appetite in obesity; also used dissolved in water as a spray to cover burned areas and as a suspending agent in pharmaceuticals and foods.
Farlex Partner Medical Dictionary © Farlex 2012


(mĕth′əl-sĕl′yə-lōs′, -lōz′)
A powdery substance that is prepared synthetically by the methylation of natural cellulose, swells in water to form a gel, and is used as a food additive, bulk-forming laxative, emulsifier, and thickener.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A highly viscous, water-soluble, non-irritating compound used as a thickening, lubricating and clinging agent in drugs such as artificial tears, wetting and contact lens solutions. See alacrima; keratoconjunctivitis sicca; artificial tears.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
References in periodicals archive ?
Among the five different formulations, F5 has the highest folding endurance due to the presence of a higher concentration of methylcellulose (2.00% w/v) when compared with the other films.
Hydroxypropyl methylcellulose E5 (HPMC) was purchased from Alfa Aesar, Germany.
Effect of anti-fungal hydroxy-propyl methylcellulose (HPMC)-lipid edible composite coatings on postharvest decay development and quality attributes of cold-stored 'Valencia' oranges.
To thicken the dispersed methylcellulose, 2-amino-2-methyl-1-propanol (hereinafter, AMP) was used as a pH controller; the properties of AMP are listed in Table 7.
Dandan, "Effect of methylcellulose on the properties of silica membrane," Journal of Membrane Science & Technology, vol.
After coculture with interleukin-6 (IL-6), interleukin-8 (IL-8), and growth-regulated oncogene [beta] (GRO-[beta]) (100ng/mL) for 3 days, CB [CD34.sup.+] cells in the upper chamber were collected, and 500 cells were placed in H4435 methylcellulose for 14 days, followed by counting different hematopoietic colonies and flow cytometry analysis.
[4] Medialisation with methylcellulose Guardiani et al.
The special riboflavin solutions used were ParaCel (riboflavin 0.25%,benzalkonium chloride, EDTA, Trometamol, hydroxypropyl methylcellulose, phosphate buffered saline solution) and vibeX Xtra(riboflavin 0.25%,phosphate buffered saline solution) (Avedro, USA).
The hydrogels used in the release study were prepared from the following polymers: methylcellulose (MC, Sigma-Aldrich, Poznan, Poland), Carbopol 980 NF (pA1, Lubrizol, Wickliffe, USA) and polyacrylate crosspolymer 11 (PC-11, Aristoflex Velvet, Clariant, Muttenz, Switzerland).
Grover, J.A., Methylcellulose and its derivatives, in Industrial gums, polysaccharides and their derivatives.