Co-methylation of some important tumor suppressor genes have been identified in some studies and it was defined as methylator
phenotype of the relevant cancer.
Iacopetta, "CpG island methylator
phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer," Clinical Cancer Research, vol.
CRC: Colorectal Carcinoma; CIN: Chromosome Instability; MSI: Microsatellite Instability; CIMP: CpG Island Methylator
Phenotype; FAP: Familial Adenomatous Polyposis, HNPCC: Hereditary Nonpolyposis Colorectal Cancer; APC: Adenomatous Polyposis Coli; MMR: Mismatch Repair; ACF: Aberrant Crypt Foci
Irahara et al., "Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator
phenotype," Clinical Cancer Research, vol.
Genetic polymorphisms in one-carbon metabolism: Associations with CpG island methylator
phenotype (CiMP) in colon cancer and the modifying effects of diet.
"If we could somehow find a way to do that in Bangladesh, it would make individuals much better methylators
of arsenic, and as this current study shows if you're a better methylator
you're at a lower risk for disease," said co-author Joseph Graziano, PhD, professor of Environmental Health Sciences and Director of Superfund Research Program at the Mailman School of Public Health of Columbia University.
This is frequently referred to as the 'methylator
(4.) Issa JE CpG island methylator
phenotype in cancer.
Diet and lifestyle factor associations with CpG island methylator
phenotype and BRAF mutations in colon cancer, Int J Cancer.
For fibromyalgia, there were 18 trials (16 were placebo-controlled) of which 11 studied TCAs,[66-73] 3 studied SSRIs,[78-80] 2 studied a methylator
(S-adenosylmethionine [SAMe]),[81,82] one studied an antiserotonin agent, and one examined a TCA, an SSRI, and a combination of both, against placebo.
BIOLOGY OF THE IDH ENZYMES: GENERATION OF 2-HG AND CREATION OF A GLIOMA-CpG ISLAND METHYLATOR
PHENOTYPE BY MUTANT IDH