methylation


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Related to methylation: acetylation

methylation

 [meth″ĭ-la´shun]
the addition of methyl groups.

meth·yl·a·tion

(meth-i-lā'shŭn),
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid, the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

[-lā′shən]
Etymology: Gk, methy, wine, hyle, matter
1 the introduction of a methyl group, CH3, to a chemical compound.
2 the addition of methyl alcohol and naphtha to ethanol to produce denatured alcohol.

methylation

Chemistry
The addition of a methyl group to a molecule.
 
Molecular biology
The addition of a methyl group to a cytosine residue on double-stranded DNA, a process which plays a major role in regulating gene expression and preventing restriction endonucleases from cutting DNA at their recognition sites.
 
Methylated genes are inactive; the pattern of methylation or imprinting is critical in gene expression, and may be passed from one generation to the next. Genes may be demethylated or methylated de novo according to the cell’s function, or during normal development. Phosphorylation is another form of semi-permanent gene control.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid; the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

the addition of a methyl group (-CH3) to an AMINO ACID in a PROTEIN, as in, for example, POST-TRANSLATIONAL MODIFICATION, or to a NUCLEOTIDE in a NUCLEIC ACID; see MODIFICATION AND RESTRICTION SYSTEM. See also METHYL TRANSFERASE.

methylation,

n a phase-II detoxification pathway in the liver; methyl groups combine with toxins to rid the body of various substances.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid.

methylation

(meth´əlā´shən),
n 1. the introduction of a methyl group, CH3, to a chemical compound.
n 2. the addition of methyl alcohol and naphtha to ethanol to produce denatured alcohol.

methylation

the addition of methyl groups.
References in periodicals archive ?
Various techniques for detecting DNA methylation patterns have been developed.
Pinctada fucata, Growth trait, Growth rate, Genome methylation, Correlation analysis.
Many studies have highlighted the relevance of DNA methylation in developmental processes (Fang and Chao, 2007).
Here we analyzed a subcohort of MoBa participants (born 2002-2004) with Illumina[R]450K methylation data measured from newborn DNA and cotinine measured from maternal plasma at about gestational week 18 of pregnancy (Joubert et al.
These results are important because methylation, as one of the mechanisms of the regulation of gene expression, affects what genes are turned on, which has implications for the development of smoking-related diseases," Stephanie J.
When methylation increases on the OXT gene, this may correspond to a reduction in this gene's activity.
In this new study, researchers developed a series of steps that uncovered telltale methylation marks in colon, lung, breast, stomach, and endometrial cancers.
The data showed a reduction in non-CG methylation is associated with impaired differentiation capacity into endodermal lineages.
For in vitro methylation studies, constructions were done using the CpG-free and promoter-less vector pCpG-free basic-Lucia (Invivogen, San Diego, CA) as the backbone.
In HNSCC, numerous studies have identified promoter DNA methylation of such genes as CDKN2A (p16), DAP kinase (DAPK), and DNA repair genes MGMT and MLH1 (8) In comparisons of epigenetic profiles of HNSCCs, there is also evidence that epigenetic changes observed in head and neck cancer are subsite dependent.
For the average milk density (AMD), the DNA methylation level of ERa gene in junior AMD group (JP) was significantly lower than that in senior AMD group (SP) (Pless than 0.