methyl salicylate

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the chemical group or radical -CH3.
methyl salicylate a natural or synthetic oil with a characteristic wintergreen odor and taste; used as a counterirritant in ointments or liniments for muscle pain and also as a flavoring agent. Called also wintergreen oil.


any salt or ester of salicylic acid; those used as drugs for their analgesic, antipyretic, and antiinflammatory effects include aspirin, choline salicylate, magnesium salicylate, and sodium salicylate. Low dosages of salicylates are used primarily for the relief of mild to moderate pain or fever; high dosages are particularly useful for treatment of rheumatoid arthritis and other rheumatoid disorders.

The mechanism of most of the effects of aspirin and other salicylates is inhibition of prostaglandin synthesis, thus blocking pyretic and inflammatory processes that are mediated by prostaglandins. Aspirin also prolongs bleeding time through its effects on platelets owing to both inhibition of prostaglandin synthesis and acetylation of platelet structures. Salicylates also cause ulceration and hemorrhagic lesions of the gastric mucosa. They act by interfering with the stomach's mucosal barrier (either directly or possibly by an effect on prostaglandins when given parenterally) so that H+ ions leak and there is subsequent damage. Aspirin should not be taken with alcohol, because this increases gastrointestinal damage. Aspirin should be avoided by persons with gastric ulcers, hemophilia, or hemorrhagic states, and by children with a viral illness.

Another problem associated with the use of salicylates is hypersensitivity. This most commonly occurs with aspirin and is less common with other salicylates. Aspirin-sensitive individuals often also react to other antiinflammatory agents, such as indomethacin, and to a yellow dye used to color foods and drugs called tartrazine or FD & C Yellow No. 5. The allergic reaction usually takes the form of edema of the face and intestinal tract and asthma. Aspirin sensitivity occurs in about 0.25–1.0 per cent of the population and is more common in persons with a history of asthma or other allergic disorders. There is a common association with nasal polyps.
Salicylate Poisoning. Mild salicylate toxicity, which can occur from high dosage therapy, has symptoms that include headache, dizziness, tinnitus, deafness, nausea, vomiting, and acid-base disturbances. If the poisoning occurs in the home, a poison control center should be contacted immediately. Large overdoses produce acute poisoning that is a medical emergency. Treatment consists of gastrointestinal decontamination, administration of intravenous fluids to correct dehydration and acid-base imbalance, and hemodialysis if serum salicylate levels are very high. Body sponging with cool water is done for hyperpyrexia. Blood salicylate levels and blood gases and electrolytes are periodically determined by laboratory tests. Life-threatening poisoning may require exchange transfusion or renal dialysis.
methyl salicylate see under methyl.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

meth·yl sa·lic·y·late

(meth'il să-lis'ĭ-lāt),
The methyl ester of salicylic acid, produced synthetically or distilled from Gaultheria procumbens (family Ericaceae) or from Betula lenta (family Betulaceae); used externally and internally for the treatment of various forms of rheumatism.
Farlex Partner Medical Dictionary © Farlex 2012

methyl salicylate

The methyl ester of salicylic acid, C8H8O3, an essential oil derived from birch or wintergreen or made synthetically, used as a counterirritant in ointments to treat muscle pain.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

methyl salicylate

An aromatic compound used externally as an embrocation often in combination with other ingredients. Also known as Oil of Wintergreen. Brand names of formulations containing methyl salicylate are Balmosa, Monphytol, Phytex, Radian B and Salonpas.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Numbers of orchid bees collected (with mean [+ or -] SE) using 4 chemical attractants (BA = benzyl acetate, EUC = eucalyptol, EUG = eugenol, MS = methyl salicylate) at Cusuco National Park, Honduras, in Jun to Jul 2013, with observed and estimated species richness values, [q.sub.0] values, and results of indicator species analysis (ISA).
The total of product taken from the vials after the five jets was 3.140 mg for the diclofenac diethylammonium and 2.910 mg for the methyl salicylate.
Methyl jasmonate and Methyl salicylate were purchased from Sigma (St.
Tenneco has incorporated methyl salicylate into RepelKote, a paperboard coating that can guard products in folding cartons from a variety of insect infestations.
Results show that air saturated with the mixture of menthol, eucalyptus and methyl salicylate (20, 15, 15%) oil (Abu Fez) inhibited growth of the three tested fungi by 100% as compared to the control (Fig.
It consists of at least one complexed trace mineral consisting of copper organically bound to pyrrolidone carboxyl-ate forming a copper-amino acid chelate; dipotassium glycyrrhizinate; at least one herbal extract; methyl salicylate; a component selected from the group consisting of methylsulfonylmethane, at least one non-steroidal anti-inflammatory alone or in combination, lysine-aspartate, at least one steroidal anti-inflammatory alone or in combination, and at least one nonsteroidal anti-inflammatory and at least one non-steroidal anti-inflammatory and a pharmaceutically acceptable carrier composition.
Traps were baited with the following treatments, with each chemical dispensed separately in hollow polyethylene stoppers (Kimble, Vineland, New Jersey) (0.5 ml): phenylacetaldehyde (PAA), PAA + [beta]-myrcene, PAA + methyl salicylate, acetic acid + 3 methyl-1-butanol (isoamyl alcohol) (AA + 3MeB) and unbaited controls.
Available for auction to Rota Gala Dinner guests will be two original artworks by UK artist Damien Hirst (Methyl Salicylate 2005 and Beautiful Magnificent: It's the Stuff of Legends).
This study, therefore, aimed to investigate and compare the therapeutic efficacy of diclofenac sodium PH (DSPH), methyl salicylate PH (MSPH) and conventional TUS therapy on patients with knee OA.
Their chips can already distinguish between methyl salicylate, a compound used to simulate the chemical warfare agent mustard gas, and toluene, a common additive in gasoline.
They use substances such as methyl salicylate (wintergreen oil), camphor, menthol and capsaicin (the substance that gives chili peppers their spiciness) to dilate blood vessels in the skin, triggering warming, cooling or other sensations at the skin's surface.