methoxamine


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methoxamine

 [mĕ-thok´sah-mēn]
a sympathomimetic amine used as a vasopressor in the treatment of acute hypotensive states, particularly to maintain blood pressure during anesthesia, and also to treat paroxysmal supraventricular tachycardia; administered intramuscularly or intravenously.

methoxamine

Cardiology A vasopressor used for hypotension and PAT; it improves performance in left ventricular dysfunction, which may be linked to exercise-induced vasodilation of airway vessels

methoxamine

An alpha-adrenergic agonist drug that constricts arteries and is sometimes used in emergency to raise falling or dangerously low blood pressure. A brand name is Vasoxine.
References in periodicals archive ?
Methoxamine, a potent alpha agonist, can also be considered in patients who do not respond to epinephrine (82).
In addition, the level of serum creatinine will also increase at situations of taking drugs (e.g., methoxamine and cimetidine) or other nonrenal disease (e.g., hyperthyroidism and acromegaly) without the rise of GFR.[48] To our knowledge, a single measurement of serum creatinine is not an ideal measure of renal function, not as sensitive and accurate as the GFR, which could lead to cover the actual correlation between renal function and HT.[8] Thus, little data existed on the relation of HT and serum urea nitrogen and creatinine to now and further investigations are still warranted.
Severi et al., "Both [Ca.sup.2+]-dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine," American Journal of Physiology--Gastrointestinal and Liver Physiology, vol.
Gardiner, "Pressor sensitivities to vasopressin, angiotensin II, or methoxamine in diabetic rats," The American Journal of Physiology--Regulatory Integrative and Comparative Physiology, vol.
Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe.
Then the vessels were exposed to methoxamine ([10.sup.-5] M), and the presence of functional endothelium was assessed by the ability of acetylcholine (ACh, [10.sup.-9] to [10.sup.-5] M) to induce relaxation.
Beta-adrenergic blockade and alpha-receptor stimulation (norepinephrine and methoxamine) can augment ST elevation in Brugada syndrome (10), whereas beta-adrenergic stimulation minimises such manifestations.
Louis, MO, USA) were used in the in vitro investigations: [[alpha].sub.1] agonist used are Methoxamine HCl, [[alpha].sub.1] antagonist Prazosin HCl and then [[alpha].sub.1] and [[alpha].sub.2] antagonist Benextramine 4 HCl as well as the [[alpha].sub.2] agonist p-Iodoclonidine hydrochloride antagonist the [beta] agonist Isoprotenol the [D.sub.2] Dopamin agonist Quinpirol dihydrochloride and the selective antagonist of [[alpha].sub.2] adreno receptor Rauwolscine.
After 10 weeks, plasma triglyceride and 15-F2t-isoprostane, and insulin sensitivity were measured, and after 12 weeks, pressor response to methoxamine (15-60 microg/kg min) was assessed.
These include (29): endothelium-derived contracting factors such as endothelin, prostanoids such as thromboxane A2 and prostaglandin F2[alpha], circulating sympathomimetics ([alpha]-adrenoceptor agonists) such as norepinephrine and synthetic [alpha]l-adrenoceptor agonists like methoxamine or phenylephrine, platelet-derived substances such as 5-hydroxytryptamine and thromboxane A2, mast cells- or basophils-derived substances like histamine, muscarinic receptor agonists such as acetylcholine, renin-angiotensin system related substances such as angiotensin II and depolarizing potassium ions.
Methoxamine (50 ug/kg), isoproterenol (0.5 uglkg) and acetylcholine (1 ug/kg) served as the [alpha], [beta] and cholinergic agonists respectively.
N-caproic acid, N,N-dimethylformamide, N,O-bis(trimethylsilyl)trifluoroacetamide, anhydrous ethanol, pyridine, ethyl chloroformate (ECF), chloroform (CHCl3), sodium hydroxide, anhydrous sodium sulfate, methoxamine hydrochloride (97%), and trypan blue stain.