These are methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase
In line with these observations, an NADPH-dependent diflavin enzyme, methionine synthase reductase
, has been shown to reduce the CBS heme in vitro in the presence of CO or nitrite, generating, respectively, the ferrous-CO or ferrous-NO CBS adducts [18, 67, 68].
Barbaux et al., "The methionine synthase reductase
(MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations," Atherosclerosis, vol.
2756GG genotype of methionine synthase reductase
gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
The MTRR (Methionine Synthase Reductase
) enzyme serves the needs of MTR by regenerating methyl-B12 from available methyl donors and BI2.
Methionine synthase (MTR), methionine synthase reductase
(MTRR), transcobalamin 2 (TC2), cystathionine beta synthase (CBS), and methylenetetrahydrofolate dehydrogenase (MTHFD1) are very important enzymes involved in folate/homocysteine (Hcy) metabolism and play essential roles in synthesis and repair of DNA and methylation reactions .
Objective: In this study, we investigated whether methionine synthase (MTR) A2756G and methionine synthase reductase
(MTRR) A66G gene polymorphisms were related with infertility.
The genes they have looked at are involved in the intracellular transport (reduced folate carrier 1 or RFC1), and conversion ([gamma] glutamyl hydrolase or GGH) of methotrxate, metabolism of purine and pyrimidine (methylenetetrahydrofolate reductase or MTHFR, thymidylate synthase or TS, methionine synthase or MS, serine hydroxymethyltransferase I or SHMT 1 , aminoimidazol carboxamide ribinucleotide transformylase or ATIC, methionine synthase reductase
or MTRR) and efflux of the drug (multidrug resistance protein 1 or MDR1).
The functional deficiency depends on mutations in the methionine synthase gene or in the gene encoding methionine synthase reductase
, an enzyme involved in the reductive activation of methionine synthase (Leclerc et al, 1998).
Methylenetetrahydrofolate Reductase (MTHFR) 677C[flecha diestra]T and Methionine Synthase Reductase
(MTRR) 66A[flecha diestra]G Polymorphisms: Association with Serum Homocysteine and Angiographic Coronary Artery Disease in the Era of Flour Products Fortified with Folic Acid.
The activity of some enzymes, such as methionine synthase, may be influenced by other enzymes, such as methionine synthase reductase
. (3) Without adequate folate and folate receptor activity, the appropriate enzyme products that lead to the reduction of homocysteine and to methionine will not be produced, nor will appropriate purine and pyrimidine synthesis occur.
(7) Another, more recent patent, also filed in 1999 and awarded May 1, 2006, is for the methods by which methionine synthase reductase
, which is in the same pathway as MTHFR and is also a cause of hyperhomocysteinemia.