methionine aminopeptidase-2

methionine aminopeptidase-2

A cobalt- and magnesium-binding cytoplasmic methionyl aminopeptidase encoded by METAP2 on chromosome 12q22, which plays a key role in regulating post-translational processing and protein synthesis, by hydrolysing N-terminal methionine from newly synthesized proteins. It is a molecular target for angiogenesis inhibitors and thus has therapeutic potential in tumour progression, diabetic retinopathy, rheumatoid arthritis, and other conditions characterised by angiogenesis.
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