Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase
Methionine, in turn, is an essential amino acid that, together with ATP, participates in the formation of SAMe, in a reaction catalyzed by methionine adenosyltransferase
Between the two isoforms of methionine adenosyltransferase
, MAT-I is inhibited and MET-III is activated by its product, AdoMet (; ).
Methionine can also be increased in methionine adenosyltransferase
I/III deficiency, S-adenosylmethionine hydrolase deficiency, glycine N-methyltransferase deficiency, generalized liver disease, and infants fed a formula rich in methionine.
Methionine is converted to SAM by methionine adenosyltransferase
Methionine is converted to S-adenosylmethionine (SAM), the major intracellular methyl donor, by methionine adenosyltransferase