methionine adenosyltransferase


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me·thi·o·nine a·den·o·syl·trans·fer·ase

an enzyme catalyzing the condensation of l-methionine and ATP, forming S-adenosyl-l-methionine, orthophosphate, and pyrophosphate; a deficiency of the hepatic enzyme will result in hypermethionemia.
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Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase.
Methionine, in turn, is an essential amino acid that, together with ATP, participates in the formation of SAMe, in a reaction catalyzed by methionine adenosyltransferase (MAT).
Between the two isoforms of methionine adenosyltransferase, MAT-I is inhibited and MET-III is activated by its product, AdoMet ([9]; [10]).
Methionine can also be increased in methionine adenosyltransferase I/III deficiency, S-adenosylmethionine hydrolase deficiency, glycine N-methyltransferase deficiency, generalized liver disease, and infants fed a formula rich in methionine.