methemoglobin reductase


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Related to methemoglobin reductase: methemoglobin reductase pathway

met·he·mo·glo·bin re·duc·tase

a flavoenzyme catalyzing the reduction of methemoglobin to hemoglobin in the red blood cell.

methemoglobin reductase

An enzyme found in significant amounts in erythrocytes that catalyzes the reduction of methemoglobin in conjunction with the coenzyme nicotine adenine dinucleotide phosphate and other enzymes.
See also: methemoglobin
References in periodicals archive ?
The patient's methemoglobin reductase activity was found to be within the reference interval, ruling out methemoglobin reductase deficiency.
Second, the conformational change renders Hb M-Boston resistant to reduction by methemoglobin reductase (10).
* Methemoglobinemia may be acquired (drug or chemically induced) or inherited (methemoglobin reductase deficiency or Hb M).
* The cause of methemoglobinemia may be assessed by measuring methemoglobin and methemoglobin reductase activity, and by performing a hemoglobinopathy investigation (acquiring a family, medication, and chemical exposure history are also critical).
The primary mode of MetHb reduction, accounting for 99% of daily MetHb reduction, is the cytochrome [b.sub.5] methemoglobin reductase (NADH methemoglobin reductase) system (26).
Infants are particularly susceptible to toxin-induced methemoglobinemia because of lowered erythrocyte cytochrome bs methemoglobin reductase activity (50-60% of adult activity) until 4 months of age (53, 54).
The ratios may be used to distinguish individuals with toxin-induced or congenital methemoglobin reductase deficiency methemoglobinemia from those with HbM variants.