They are available in both topical therapy as dorzolamide (Trusopt) or brinzolamide (Azopt) and in tablet form as acetazolamide (Diamox) and methazolamide
Stavrovskaya et al., "Methazolamide
and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury," Stroke, vol.
The toxicity of four CA inhibitors (CA1): acetazolamide (AZM), methazolamide
(MZM), ethoxolamide (ETX) and dorzolamide (DZA) were evaluated in larvae of Anopheles albimanus by monitoring mortality 24, 48 and 72 hours post application, at a concentration of 50 ug/ml diluted in dimethyl sulfoxide previously.
These include acetazolamide (Diamox), dichlorphenamide (Daranide) and methazolamide
Lee, "In rare instances, if eye drops don't bring your eye pressure down to the desired level, oral medication may need to be taken." Commonly prescribed drugs include acetazolamide (Diamox) and methazolamide
Table 2 Drugs Associated With the Development of PRCA * Antibiotic Isoniazid Cephalothin Chloramphenicol Dapsone Penicillin Antiepileptic Diphenylhydantoin Carbamazepine Sodium valproate Antiinflammatory Fenoprofen Sulfasalazine Cardiovascular Procainamide Chemotherapeutic Rifampicin Erythropoietic Recombinant erythropoietins Other agents Azathioprine Chlorpropamide Allopurinol Methazolamide
Penicillamine Phenobarbital * Note: Adapted from Dessypris, E.N.
To evaluate the effectiveness of the method used to determine CA inhibition, a series of assays were performed under the same experimental conditions but in the presence of different concentrations of sulfonamide CA inhibitors (acetazolamide, methazolamide
, and sulfanilamide) dissolved in the same starting solution (HEPES buffer) before the beginning of the assay.
Miscellaneous medications: clofibrate, dichlorphenamide, fenfluramine, ketoconazole, methadone, methazolamide
, norethindrone, thiabendazole