methanol

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methanol

 [meth´ah-nol]
a poisonous colorless liquid used as a solvent and fuel; ingestion may cause blindness or death. Called also methyl or wood alcohol.

meth·yl al·co·hol

CH3OH; a flammable, toxic, mobile liquid, used as an industrial solvent, antifreeze, and in chemical manufacture; ingestion may result in severe acidosis, visual impairment, and other effects on the central nervous system.

methanol

A polar alcohol used as an industrial solvent; it is miscible with water, ethanol, ether, and petroleum derivatives (e.g., gasoline), and can be found in canned fuel and in antifreeze, from which it may be abused as an inebriant by indigent alcoholics. Methanol is metabolised to formaldehyde and formate, causing severe metabolic acidosis, optic nerve damage and blindness.
 
Toxic range
60–250 ml; as little as 15 ml can be fatal.

Management
Overload patient with ethanol, which competes with methanol for sites on alcohol dehydrogenase, reducing methanol metabolites and toxicity.

methanol

Toxicology A polar alcohol used as an industrial solvent miscible with water, ethanol, ether, petroleum derivatives–eg, gasoline, in canned fuel and in antifreeze, where it may be abused as an inebriant by indigent alcoholics; methanol is metabolized to formaldehyde and formate, causing significant metabolic acidosis and optic nerve damage and blindness Toxic range 60-250 ml; as little as 15 ml has been fatal Management Overload Pt with ethanol–which competes with methanol for sites on alcohol dehydrogenase, reducing methanol metabolites and toxicity

meth·yl al·co·hol

(meth'il al'kŏ-hol)
A flammable, toxic, mobile liquid, used as an industrial solvent and antifreeze, and in the manufacture of chemicals; ingestion may result in severe acidosis, visual impairment, and other effects on the central nervous system.
Synonym(s): methanol.

meth·yl al·co·hol

(meth'il al'kŏ-hol)
Flammable toxic liquid, used as an industrial solvent, antifreeze, and in chemical manufacture; ingestion may result in severe acidosis and other effects on the central nervous system.
Synonym(s): methanol.
References in periodicals archive ?
The degree of change in ion formation appeared to correlate with the percentage of methanol required to elute the compound of interest.
When 1 lot of Riedel-de Haen Chromasolv LC-MS methanol, which had shown a mean 16% signal reduction for 32-desmethoxyrapamycin (Fig.
Resuts for mixing experiments, drug stability studies, analysis of patient blood extracts, and postcolumn infusion experiments confirm that the methanol used in LC-MS/MS can be associated with ionization changes during ESI MS.
My data show that the relative intensities of ammonium, sodium, and potassium adduct ions differed with the methanol type used in the mobile phase.
In the case of sirolimus and tacrolimus, the structural analog internal standards eluted at the same time, or very close to the specific drug of interest (i.e., same percentage of methanol).