methaemoglobinaemia


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methaemoglobinaemia

A condition characterised by excess (> 3%) methaemoglobin in the circulation.

Clinical findings
Cyanosis, headache, dyspnoea, fatigue, drowsiness, ataxia, stupor.

met·he·mo·glo·bi·ne·mi·a

(met-hē'mŏ-glō-bi-nē'mē-ă)
The presence of methemoglobin in the circulating blood.
Synonym(s): hemiglobinemia, methaemoglobinaemia.
[methemoglobin + G. haima, blood]

methaemoglobinaemia

The presence of METHAEMOGLOBIN in the blood in excess of the normal 1%. This may occur as a hereditary condition or as a result of absorption of nitrites from the intestine. Methaemoglobinaemia causes CYANOSIS.

met·he·mo·glo·bi·ne·mi·a

(met-hē'mŏ-glō-bi-nē'mē-ă)
The presence of methemoglobin in the circulating blood.
Synonym(s): methaemoglobinaemia.
[methemoglobin + G. haima, blood]
References in periodicals archive ?
Methaemoglobinaemia occurs when there is deficiency in the reducing enzyme activity, when haemoglobin M, an autosomal dominant condition which results in a variant haemoglobin with an amino acid substitution at or near the haem group, such that methaemoglobin becomes unusually resistant to reduction; or in patient with acquired or drug-induced methaemoglobinaemia (2,7).
Severe acute methaemoglobinaemia requires immediate therapy, whereas chronic asymptomatic patients will not require active therapy and in case of hereditary methaemoglobinaemia there is no pharmacological treatment available.
It is associated with mild methaemoglobinaemia of little clinical significance, and acute haemolysis in people with G6PD deficiency.
Methaemoglobinaemia secondary to topical lignocaine/ prilocaine in a circumcised neonate.
Higher levels of nitrate could result in Methaemoglobinaemia. Nitrate level was found in the range of 0.03-20.3 mg/L (Table 2) with mean value of 1.96+-4.7.
Poisoning in children: methaemoglobinaemia. An Sist Sanit Navar.
25 November 2011 - Japanese pharmaceutical company Daiichi Sankyo Co Ltd (TYO:4568) said Friday it has signed a licence agreement for the development of Methylthioninium chloride solution for injection from French Provepharm SAS, for the treatment of life-threatening medicinal and chemical products induced methaemoglobinaemia in Japan.
Acute DDS poisoning is potentially lethal due to severe methaemoglobinaemia and haemolytic anaemia.