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- because these chemical receptors remain blocked by methadone for up to 24 hours, even if a person addicted to heroin takes heroin after the administration of methadone, this person is not likely to feel the same effects of the heroin as he or she previously felt;
- because the action of methadone is associated with slower and less intense withdrawal symptoms than those of heroin, the patient can experience milder opiate effects while the addiction is being treated and avoid the unpleasant withdrawal symptoms associated with heroin.
- alcohol abuse
- brain disease or head injury
- drug dependency, particularly of narcotics
- emotional problems
- emphysema, asthma, or other chronic lung disease
- enlarged prostate
- gallstones or gallbladder disease
- heart disease
- kidney disease
- liver disease
- problems with urination
- underactive thyroid
- urine retention
- abnormally fast or slow heartbeat
- blurred or double vision
- cold, clammy skin
- depression or other mood changes
- dry mouth
- loss of appetite
- nightmares or unusual dreams
- pinpoint pupils of the eyes
- redness or flushing of the face
- rigid muscles
- ringing or buzzing in the ears
- severe drowsiness
- skin reaction at the site of injection
- stomach cramps or pain
- trouble sleeping (insomnia)
- yellowing of the skin or whites of the eyes
methadone/meth·a·done/ (meth´ah-dōn) a synthetic opioid analgesic with actions similar to those of morphine and heroin, and almost equal in potential for addiction; the hydrochloride salt is used as an analgesic and in the management of heroin addiction.
methadoneA synthetic, relatively long-acting oral opioid analgesic used primarily for narcotic detoxification and controlled maintenance of heroin addiction.
Severe pain; antitussive.
Lightheadedness, dizziness, anorexia, nausea and vomiting, dry mouth, sweating, drowsiness, hypotension, decreased intestinal motility, respiratory depression.
Inducers of methadone metabolism
Phenytoin, carbamazepine, rifampicin, fluconazole, some protease inhibitors—all via CYP3A4 induction.
Respiratory depression, stupor, coma, loss of short-term memory.
Methadone overdose, autopsy findings
Airway obstruction, pulmonary oedema, aspiration of vomit, bronchopneumonia, cardiac arrest/failure.
Amidone, dollies, dolls, done, fixer, fizzies, juice, juicer, medecina, meth-a-done, pixie, synthetic heroin, wafers.
methadoneDolophine®, Methenex® Substance abuse A synthetic, relatively long-acting oral opioid analgesic Uses Severe pain; narcotic detoxification, controlled maintenance of addiction Effects ↓ intestinal motility; respiratory depression; analgesic; antitussive Overdose effects Respiratory depression, stupor, coma, loss of short-term memory. See Heroin, Opioids.
methadoneA synthetic narcotic painkilling (analgesic) drug with properties similar to those of MORPHINE. It is also used as a substitute for HEROIN in attempts to manage addiction, but is widely abused. A brand name is Physeptone.
Patient discussion about methadone
Q. I would like to chat with someone w/any knowledge of fibromyalgia being treated with Methadone my best friend has severe fibromyalgia and has been treated with Methadone for the past several years. She has developed severe chronic anemia in these years. She now has lymphoma. I want to know if she is the only one and if methadone can affect bone marrow.
the Anemia is probably due to the Lymphoma. if not-her life is out of balance, she might changed her diet and may have shortage of iron or B12.