methacholine


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Related to methacholine: Methacholine challenge test

methacholine

 [meth″ah-ko´lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects; it has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.
References in periodicals archive ?
Coronary arteriogram and left ventriculogram during angina attack induced by methacholine. N.
Asthma was confirmed at any methacholine challenge if there was a 20% decrease in [FEV.sub.1] from baseline at a methacholine concentration of [less than or equal to] 8 mg/mL; these patients were restarted on appropriate medications.
Change in specific airway resistance (sRaw) of mice after being sensitized and challenged with ovalbumin and inhalation of different concentrations of methacholine compared with the control group (P<0.05).
Caption: Figure 2: Effect of anti-IL-5 mAb and ABPS treatment on hyperresponsiveness induced by methacholine. Airway response of control, asthma group, or therapy group to methacholine (24 h after exposure to HDM).
Nondiabetic mice sensitized and challenged with OVA showed an increased Penh to 3 and 6 [micro]g/mL of methacholine aerosolization as compared to sensitized mice challenged with saline.
Mice were stimulated by increasing concentrations of methacholine (0, 10, 30, and 100mg/ml), and airway resistances of different groups are shown.
CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure.
After a stable baseline was achieved, mice were given aerosolized PBS or various concentrations of methacholine (6.25, 12.5, 25, or 50 mg/mL) via a jet nebulizer in the chamber.
Second, we aimed to determine the magnitude of changes in different IOS parameters and their deviations to guide clinicians on when they should stop the methacholine challenge test.
The bronchoprotective effect refers to the reaction of the airways to challenge by provocative stimuli such as allergens or irritants and is measured with doses of histamine, methacholine, or cold air.
The results of peak expiratory flow monitoring, and even shifts in paired methacholine tests and induced sputum eosinophil offwork versus at-work may show similar changes in those with the WEA and those with OA [9].