metastatic sequence

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Related to metastatic cascade: metastatic tumor, intravasation

metastatic sequence

A series of events that occurs in the cells of a primary tumour, which facilitate the development of a tumour at a metastatic site.
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They are of particular interest to researchers given that they can be implicated in various steps of the metastatic cascade and thus may have therapeutic value.
It is believed that downregulation of MSGs is a critical step to enable tumor cells to complete the metastatic cascade. To date, a total of thirteen MSGs have been characterized in cancer in general, although research on the potential prognostic and therapeutic value of MSGs in UM is not well characterized [10,11].
The different cellular processes along the metastatic cascade are also subject to variable regulation in time including periods of metastatic latency [9].
(1) Each of the molecules selected in the current study contribute to some of the above steps, all of which appear crucial in the metastatic cascade. Briefly, HER2/neu is functionally integrated with the epithelial-mesenchymal transformation that the tumor cells have to undergo to acquire migratory capabilities; the lymphocyte homing receptor CD44v6, an ubiquitous cell surface adhesion molecule, is involved in cell-cell and cell-matrix organization; the physical association of E-cadherin and [beta]-catenin is believed to be critical to homotypic cell-cell adhesion.
DTC research has paved the way to a better understanding of the single steps of the metastatic cascade by studying occult metastatic seeds that propel the sprouting of secondary life-threatening lesions, including the discovery of new putative metastasis-suppressor genes (4).
Thus far, little is known about the triggers that control the fine balance between the EMT and MET during the metastatic cascade (27).
The EPISPOT assay, a multiparameter technology that reveals a unique fingerprint of proteins secreted by single viable DTC, opens a new avenue in the understanding of the biology of the metastatic cascade. This information may be used in the future for improved molecular staging and treatment monitoring of cancer patients.
Dissecting the metastatic cascade. Nat Rev Cancer 2004;4:448-56.
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