metastatic


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met·a·stat·ic

(met'ă-stat'ik),
Relating to metastasis.

metastatic

See metastasis.

brain tumor

Neurology A neoplasm affecting the brain which may be 1º–brain or meninges, or 2º–ie metastatic to the brain; malignant gliomas account for 2.5% of all cancer-related deaths; BTs are the 3rd most common CA in ages 15-34; 35,000 BTs occur/yr–US; 1st-degree relatives of children with brain tumors have a 5-fold ↑ in the risk of CNS tumors, leukemia, and other childhood tumors in the affected family Clinical Seizures, vision or hearing loss, hemiparesis, double vision, headache, weird behavior, N&V, memory loss Imaging MRI without and with contrast, CT Management Surgery, gamma knife radiotherapy are often effective; chemotherapy, immunotherapy are not. See Gamma knife.
Brain tumors/masses
Primary
Nonneoplastic
Craniopharyngioma, colloid cysts
Primary–benign
Meningioma, pituitary adenoma, acoustic neuroma, epidermoid tumors, choroid plexus papilloma
Primary–low grade
Pilocytic astrocytoma, astrocytoma, hemangioblastoma, oligodendroglioma, ganglioglioma
Primary–malignant
Anaplastic astrocytoma, glioblastoma multiforme, ependymoma, lymphoma, medulloblastoma, primitive neuroectodermal tumor, germ cell tumor, pineal cell tumor, chordoma, choroid plexus carcinoma
Metastatic
Carcinoma, meningeal carcinomatosis
.

met·a·stat·ic

(met'ă-stat'ik)
Relating to metastasis.

metastasis

(mĕ-tăs′tă-sis) plural.metastases [″ + stasis, stand]
1. Movement of bacteria or body cells (esp. cancer cells) from one part of the body to another.
Enlarge picture
METASTASES: CT scan of liver (upper left) with round metastatic tumors (Courtesy of Harvey Hatch, MD, Curry General Hospital)
2. Change in location of a disease or of its manifestations or transfer from one organ or part to another not directly connected. See: illustration

The usual application is to the manifestation of a malignancy as a secondary growth arising from the primary growth in a new location. The malignant cells may spread through the lymphatic circulation, the bloodstream, or avenues such as the cerebrospinal fluid.

metastatic (mĕt″ă-stăt′ĭk), adjective

Metastatic

The term used to describe a secondary cancer, or one that has spread from one area of the body to another.
Mentioned in: Coagulation Disorders

metastatic

pertaining to or of the nature of a metastasis.
metastatic abscesses
abscesses seeded down in tissues distant from a mother abscess.
metastatic calcification
deposition of calcification in soft tissues, e.g. muscles and connective tissue.
metastatic cascade
the series of events leading to metastasis, starting with detachment of neoplastic cells from the primary site through to attachment and tumor growth at a distant site.
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References in periodicals archive ?
The atypical aspect of this case is that our patient was a female nonsmoker with a relatively small laryngeal tumor who developed late metastatic dissemination to the brain, lungs, and pelvis.
Poorly differentiated neuroendocrine tumor of the larynx: challenging and highly aggressive
Coverage of the Metastatic Hormone Refractory Prostate Cancer pipeline on the basis of route of administration and molecule type.
Research and Markets: Metastatic Hormone Refractory Prostate Cancer - Pipeline Review, H2 2012
The NM23 mRNA levels were found to decline in tumors from women with many involved lymph nodes, an indicator of high metastatic potential," she says.
Genetic roadblocks: the body may not always resist cancer, but it does have built-in barricades to slow the spread
In such a case, it is possible that the neck mass itself is the primary tumor or that the neck mass represents a metastatic deposit with spontaneous regression of the primary elsewhere; only four such cases have been described.
Metastatic seminoma with cervical lymphadenopathy as the initial manifestation
Expression was greater in the metastatic lymph nodes than in the primary tumors, as evidenced by the greater intensity of immunofluorescence staining of EphB4 in the lymph nodes.
Expression of EphB4 in head and neck squamous cell carcinoma
Devise corrective measures for pipeline projects by understanding Metastatic Renal Cell Carcinoma pipeline depth and focus of Metastatic Renal Cell Carcinoma therapeutics.
Research and Markets: Metastatic Renal Cell Carcinoma - Pipeline Review, H2 2012
Findings on frozen-section analysis were consistent with a metastatic sarcoma.
Cystosarcoma phyllodes metastatic to the mandible: report of a rare case and literature review. (Original Article)
Written by a team from leading cancer centres in Europe, including the UK's Royal Marsden Hospital, the Handbook of Metastatic Breast Cancer, Second Edition provides advanced scientific information and guidance on clinical problems associated with metastatic breast cancer.
Research and Markets: Handbook of Metastatic Breast Cancer
1-3) In contrast, the literature contains only 26 cases of renal cell carcinoma metastatic to the nose and only eight cases metastatic to the tongue.
A case of renal cell carcinoma metastatic to the nose and tongue. (Original Article)
Global Markets Direct's, 'Metastatic Pancreatic Cancer - Pipeline Review, H2 2012', provides an overview of the Metastatic Pancreatic Cancer therapeutic pipeline.
Research and Markets: Metastatic Pancreatic Cancer - Pipeline Review, H2 2012
2) In rare but clearly documented cases, some metastatic lesions were cutaneously implanted following percutaneous transhepatic biliary drainage.
Cholangiocarcinoma metastatic to the neck: first report of a case
This report provides information on the therapeutic development for Metastatic Liver Cancer, complete with latest updates, and special features on late-stage and discontinued projects.
Research and Markets: Metastatic Liver Cancer - Pipeline Review, H2 2012

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