metastatic

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met·a·stat·ic

(met'ă-stat'ik),

Relating to metastasis.

brain tumor

Neurology A neoplasm affecting the brain which may be 1º–brain or meninges, or 2º–ie metastatic to the brain; malignant gliomas account for 2.5% of all cancer-related deaths; BTs are the 3^rd most common CA in ages 15-34; 35,000 BTs occur/yr–US; 1^st-degree relatives of children with brain tumors have a 5-fold ↑ in the risk of CNS tumors, leukemia, and other childhood tumors in the affected family Clinical Seizures, vision or hearing loss, hemiparesis, double vision, headache, weird behavior, N&V, memory loss Imaging MRI without and with contrast, CT Management Surgery, gamma knife radiotherapy are often effective; chemotherapy, immunotherapy are not. See Gamma knife.

Brain tumors/masses

Primary
Nonneoplastic: Craniopharyngioma, colloid cysts
Primary–benign: Meningioma, pituitary adenoma, acoustic neuroma, epidermoid tumors, choroid plexus papilloma
Primary–low grade: Pilocytic astrocytoma, astrocytoma, hemangioblastoma, oligodendroglioma, ganglioglioma
Primary–malignant: Anaplastic astrocytoma, glioblastoma multiforme, ependymoma, lymphoma, medulloblastoma, primitive neuroectodermal tumor, germ cell tumor, pineal cell tumor, chordoma, choroid plexus carcinoma
Metastatic: Carcinoma, meningeal carcinomatosis

met·a·stat·ic

(met'ă-stat'ik)

Relating to metastasis.

metastasis

(mĕ-tăs′tă-sis) plural.metastases [″ + stasis, stand]

1. Movement of bacteria or body cells (esp. cancer cells) from one part of the body to another.

METASTASES: CT scan of liver (upper left) with round metastatic tumors (Courtesy of Harvey Hatch, MD, Curry General Hospital)

2. Change in location of a disease or of its manifestations or transfer from one organ or part to another not directly connected. See: illustration

The usual application is to the manifestation of a malignancy as a secondary growth arising from the primary growth in a new location. The malignant cells may spread through the lymphatic circulation, the bloodstream, or avenues such as the cerebrospinal fluid.

metastatic (mĕt″ă-stăt′ĭk), adjective

Metastatic

The term used to describe a secondary cancer, or one that has spread from one area of the body to another.

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References in periodicals archive ?

With these additions, the trial now includes 20 expansion cohorts and four exploratory cohorts and aims to enroll up to 1,732 patients with advanced or metastatic solid tumors such as renal cell carcinoma and urothelial carcinoma, among others.

Exelixis Updates Phase 1b COSMIC-021 Trial of Cabozantinib in Combination with Atezolizumab in Patients with Advanced Solid Tumors

The objective of this study was to evaluate, from a Canadian public payer perspective, the cost-effectiveness of 6 cycles of docetaxel plus ADT compared to ADT alone to treat patients with high-volume metastatic HSPC.

Cost-effectiveness of docetaxel in high-volume hormone-sensitive metastatic prostate cancer

As of data cutoff on March 1, 2018, 21 patients with metastatic NSCLC who either had no prior therapy or had received up to two prior lines of therapy were enrolled in this Phase 2 cohort.

Eisai: New Data from Investigational Study of Lenvima (Lenvatinib) and Keytruda (Pembrolizumab) Combination in Three Different Tumor Types Presented at the Society for Immunotherapy of Cancer's 33rd Annual Meeting

IHC staining is important for diagnosis and treatment, and IHC markers commonly used for the diagnosis of primary RCC are PAX2, PAX8, RCC marker, CD10, and a combination of vimentin and CK.[9] However, the correct diagnosis of metastatic RCC remains challenging because the morphology of metastatic RCC differs from that of primary RCC.

Metastatic renal cell carcinoma of pancreas without a detectable primary tumor mimicking pancreatic cancer: A case report and review of the literature

Survival rates for someone with metastatic breast cancer really depend on the type of breast cancer, said Dr.

Metastatic breast cancer survival rates increasing

"Aggressive local therapy in the setting of metastatic disease needs to be studied carefully before clinical adoption."

No Benefit for Aggressive Therapy in Metastatic Prostate Cancer; However, mortality higher with conservative therapy in locally advanced, non-metastatic prostate cancer

Patients with advanced breast cancer require extensive care and intensive use of medical and other resources, but, until this study, there were no reliable estimates of the number of women actually living with metastatic disease in the United States, the authors said.

Survival rates rise for younger women with de novo MBC

These results provide an initial step toward the improvement of lung cancer therapy that is based on measurement of the expression of genes in the metastatic lymph nodes.

CIRCADIAN CLOCK-REGULATED DNA REPAIR GENE XPA IS DOWNREGULATED IN METASTATIC OF LUNG CANCER

Treatment for metastatic disease remains unsatisfactory.

A rare case of disseminated malignant melanoma

Preoperative lymphoscintigraphy showed a focus of increased activity in the left axilla, which was removed and negative on final pathology for metastatic melanoma.

Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

The key point in RCC presenting with a sinonasal metastasis is differential diagnosis with primary tumors such as adenocarcinomas, angiofibromas, hemangiopericytomas, melanomas, hemangiomas, metastatic tumors from the breast and lungs, and, more rarely, systemic diseases such as Wegener's and midline granulomas [48].

Metastatic Renal Cell Carcinoma Presenting as a Paranasal Sinus Mass: The Importance of Differential Diagnosis

[1,6] Current acceptable standards of practice include intraoperative frozen sections of SLN for the detection of metastatic breast carcinoma.

Histological and immunohistochemical evaluation of sentinel lymph nodes in breast cancer at a tertiary hospital in the Western Cape, South Africa