metaplastic carcinoma

met·a·plas·tic car·ci·no·ma

a carcinoma in which some of the tumor cells are spindle shaped, suggesting a sarcoma, or in which the stroma shows foci of bone or cartilage; such carcinomas occur in the upper respiratory or alimentary tract or in the breast.

metaplastic carcinoma (breast)

A heterogeneous group of basal phenotype tumours that comprise ± 1% of invasive breast carcinomas, which are characterised by an intimate admixture of adenocarcinoma with dominant areas of spindle cell, squamous and/or mesenchymal differentiation.

DiffDx
Metastatic carcinoma, primary sarcoma, fibromatosis, phyllodes tumour.

Metaplastic carcinoma types
• Pure epithelial—Squamous cell carcinoma, adenocarcinoma or adenosquamous with spindle differentiation.
• Mixed epithelial-mesenchymal—Carcinoma with chondroid or osseous metaplasia, carcinosarcom.

met·a·plas·tic car·ci·no·ma

(met'ă-plas'tik kahr'si-nō'mă)
A malignancy in which some of the tumor cells are spindle shaped, suggesting a sarcoma, or in which the stroma shows foci of bone or cartilage.
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References in periodicals archive ?
The histopathologic diagnoses of the malignant breast tissues included 2 ductal carcinoma in situ, 2 invasive lobular carcinoma, 10 invasive ductal carcinoma, 1 mixed ductal and lobular carcinoma, 1 invasive micropapillary carcinoma, and 1 metaplastic carcinoma. The grayscale and pseudocolored CFM images of the breast tissue fragments showed that 25 were benign and 15 were malignant, in contrast to 23 benign and 17 malignant diagnoses with the H&E-stained tissue sections.
Keywords: Metaplastic carcinoma, Chemotherapy, Radiotherapy, Surgery.
Low-grade fibromatosis-like spindle cell metaplastic carcinoma: a basal-like tumour with favorable clinical outcome.
In addition some spindle cell metaplastic carcinoma may appear with lack of epithelial differentiation; however they usually show at least reactivity for one or more keratins.
Mammographically, metaplastic carcinoma generally appears as a high-density mass with circumscribed, obscured, irregular, or spiculated margins.
Several pathologists reported this carcinoma as a subtype of metaplastic carcinoma (3).
Verrucous carcinoma, adenoid squamous carcinoma, basal cell carcinoma and sarcomatoid or metaplastic carcinoma are some of the unusual histological variants of vulvar squamous cell carcinoma.
Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type.
Diagnosis of metaplastic carcinoma could not be done because FNA smears predominantly contain malignant ductal epithelial cells with few spindle cells.
(12) Recurrent dermatofibroma, hypertrophic scars, keloid, skin manifestations of myofibroblastoma, metaplastic carcinoma, and fibromatosis are the most potential clinical differential diagnoses for DFSP tumors.
Endometrial carcinomas can be further classified by histology as endometrioid adenocarcinoma, serous adenocarcinoma, clear cell adenocarcinoma, mixed cell carcinoma, mucinous adenocarcinoma, metaplastic carcinoma (carcinosarcoma), squamous cell carcinoma, transitional cell carcinoma, small cell carcinoma, undifferentiated carcinoma, and others (4).
One case that has been misdiagnosed as metaplastic carcinoma (osteoid-chondroid type) was overtreated with a mastectomy [7].