metaplasia


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metaplasia

 [met″ah-pla´zhah]
the change in the type of adult cells in a tissue to a form abnormal for that tissue. adj., adj metaplas´tic.
agnogenic myeloid metaplasia the primary or idiopathic form of myeloid metaplasia, which is often accompanied by myelofibrosis; it is considered one of the myeloproliferative disorders. Called also aleukemic or nonleukemic myelosis.
myeloid metaplasia the occurrence of myeloid tissue in extramedullary sites; specifically, a syndrome characterized by splenomegaly, anemia, nucleated erythrocytes and immature granulocytes in the circulating blood, and extramedullary hematopoiesis in the liver and spleen. The primary form is called agnogenic myeloid metaplasia. The secondary or symptomatic form may be associated with various diseases, including carcinomatosis, tuberculosis, leukemia, and polycythemia vera.

met·a·pla·si·a

(met'ă-plā'zē-ă),
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
Synonym(s): metaplasis (2)
[G. metaplasis, transformation]

metaplasia

(mĕt′ə-plā′zhə)
n.
1. Normal transformation of tissue from one type to another, as in the ossification of cartilage to form bone.
2. Transformation of cells from a normal to an abnormal state.

met′a·plas′tic (-plăs′tĭk) adj.

metaplasia

The conversion of one type of adult tissue and/or cells—most commonly epithelia—into another; e.g., squamous metaplasia, in which non-keratinised squamous epithelium replaces ciliated columnar cells in the bronchi of smokers.

Metaplasia types
• Intestinal metaplasia—occurs in the stomach, especially in stomachs that later develop adenocarcinoma. 
• Paneth cell metaplasia and enterochromaffin cell metaplasia—occur in the gallbladder, and are associated with adenocarcinoma of same.  
• Squamous metaplasia—the transformation of glandular or ciliated epithelium to stratified sqamous epithelium. In SM of the upper respiratory tract, squamous epithelium replaces ciliated columnar epithelium; this event, particularly common in smokers, feeds the controversy that this metaplasia may represent a dysplastic process with premalignant potential. Squamous metaplasia of the endocervix is not associated with malignancy. 
• Tubal metaplasia of the endometrium—i.e., replacement of the normal endometrial glands with ciliated (fallopian) tubal cells—may occur in endometrial polyps, mild adenomatous hyperplasia and in senile endometrium, but is rarely (and then only coincidentally) associated with malignancy.

met·a·pla·si·a

(met'ă-plā'zē-ă)
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
[G. metaplasis, transformation]

metaplasia

An abnormal change in the character or structure of a tissue as a result of changes in the constituent cells. Metaplasia often involves a change of cells to a less specialized form and may be a prelude to cancer.

metaplasia

the transformation of a tissue to another form.

met·a·pla·si·a

(met'ă-plā'zē-ă)
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
[G. metaplasis, transformation]

Patient discussion about metaplasia

Q. what is metaplasia i had 2 surgeries in my left breast for some cyst they found metaplasia in the biopsy

A. from what i remember while reading on the subject- cells can go through different changes. one of them is metaplasia- change of form. our body is amazingly flexible, and under stress cells can change form and function. like if you have continues heartburns, cells in your esophagus will change to cells similar to the stomach and start excreting anti acid materials. finding that on a biopsy means the cells in the cyst changed function.

Q. what is fragments of endocervical glandular mucosa with inflammation and squamous metaplasia fragments of endocervical glandular mucosa

A. It means that part of the mucose on the cervix area has changes from a certain kind of mucose cells to another, and that there is a bit of an inflammation around it. This should be brought to the knowledge of a gynecologist and be monitored by him/her.

More discussions about metaplasia
References in periodicals archive ?
However, CG developed as early as in childhood, and often accompanied by Helicobacter pylori contamination of antral mucus, has a persistent recurrent course in adult patients complicated by mucosa transformations in the form of atrophy, metaplasia and dysplasia.
Neutrophilic infiltrate in biopsy is strongly associated with the presence of H pylori.18 A study conducted in Kosovo involving Hp gastritis cases found atrophy in 14.9% cases and intestinal metaplasia in16.2% cases in their benign gastric lesions.19 In the current study, atrophic gastritis was found in only 0.9% cases and intestinal metaplasia in only 2.7% cases.
As shown in the pathological image (Figure 4(a)), the tumor consisted mainly of hyperplastic Brunner's gland cells, rather than gastric foveolar metaplasia or adenocarcinoma components.
Biopsy sampling on endoscopic examination indicated the underlying pathology and provided valuable information regarding presence or absence of gastritis, its grade, activity, glandular atrophy, intestinal metaplasia, etiological factors like H.Pylori as well as topography.
Immunohistochemical analysis of apocrine breast lesions: consistent overexpression of androgen receptor accompanied by the loss of oestrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ.
In addition, immunohistochemical studies and mucin profiling to estimate intestinal metaplasia mucin expressions, among other tests were also conducted.
The cytological findings such as squamous metaplasia, hyperkeratosis, parakeratosis, and reactive cellular changes were noted specifically in patients with or without uterine prolapse.
Osseous metaplasia in mucosal polyps of the tongue, stomach, and intestines has been reported before.
Intestine metaplasia was observed in 12% (29/41) of the control patients, 53% (19/36) in Group A patients, and 55% (6/11) in Group B patients.
Adenomatous hyperplasia expressed less Hyal-1 than did squamous metaplasia (P=0.004), squamous cell carcinoma (P<0.01) or adenocarcinoma (P<0.01; Figure 3A).
pylori colonization 0,09 0,2 of the gastric mucosa gastrin-17 and activity of gastritis -0,27 -0,26 gastrin-17 and mononuclear infiltration -0,2 -0,13 gastrin-17 and intestinal metaplasia -0,1 -0,06 gastrin-17 and anti-Hp IgG 0,01 0,08 gastrin-17 and dysplasia -0,1 -0,06 gastrin-17 and pepsinogen-1 -0,29 -0,44 Comparative parameters n t gastrin-17 and antral atrophic gastritis 358 17,8 gastrin-17 and patient's age 358 1,11 gastrin-17 end disease durability 358 0,77 gastrin-17 and palpation pain 358 5,23 gastrin-17 and H.
When she was 19, cold punch biopsy specimens were obtained under cystoscopic guidance and the histopathological report indicated chronic cystitis and focal intestinal metaplasia. The patient came to our clinic a year ago because of her persistent symptoms.